Prin. Scientist, Clinical Research

Principal Scientist (Director) – Translational Medicine – Oncology

Principal Scientist (Director) in Translational Medicine – Oncology, responsible for early clinical development of novel therapeutics, working closely with Discovery Sciences and late‑stage Clinical Research across all therapeutic areas within the Research Division.

• Lead early clinical development strategy for novel therapy programs from Preclinical Candidate approval through Clinical Pharmacology testing (Phase1) and Proof‑of‑Concept (Phase2).
• Develop biomarker strategies cross‑functionally from First‑in‑Human studies through clinical Proof‑of‑Concept, including Experimental Medicine studies to validate biomarker platforms.
• Partner with discovery research teams to bring a clinical perspective into target identification and validation; design and execute clinical studies to evaluate target relevance.
• Develop and execute clinical pharmacology strategies to support later development stages (Phase2 through worldwide marketing application).
• Design and oversee PhaseI studies; collaborate with clinical study support staff and scientists (discovery research, biostatistics, drug metabolism, modeling & simulation, regulatory affairs, global clinical trials operations).
• Provide clinical pharmacology support for worldwide marketing application filing, including registration documents and presentations.
• Communicate study results clearly and timely to therapeutic area governance, functional area experts, and development review committees.
• Contribute to internal and external opportunities identified by Business Development and Licensing.
• Interface with key functions and research sites worldwide.

• MD/PhD or MD (clinical experience in internal medicine, pathology, or oncology). Clinical Board Certification preferred.
• Strong background in basic and/or clinical translational research with a proven record of scientific scholarship.
• Experience in oncology preferred; ability to work collaboratively across therapeutic areas.
• Demonstrated skill in clinical development, protocol development, scientific writing, and strategic thinking.
• Excellent interpersonal, writing, and presentation skills; ability to thrive in a team environment.
• Experience with translational research and/or early clinical development preferred but not required.

• Clinical Development, Clinical Research, Early Clinical Development, Ethical Compliance, Internal Medicine, Pharmaceutical Development, Pharmacokinetics, Protocol Development, Scientific Writing, Strategic Thinking, Translational Research.

• Experience in oncology and translational research.

San Francisco, California (preferred for residents; open to non‑residents unless specified).

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. We are a federal contractor and comply with affirmative action requirements for protected veterans and individuals with disabilities.

Salary range: $ – $. Eligible for annual bonus and long‑term incentives, if applicable. Comprehensive benefits including medical, dental, vision, retirement (401(k)), paid holidays, vacation, and sick days.