Senior Manager, Biotherapeutics R&D

Job Overview

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter, less invasive, and solutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions to deliver breakthroughs of tomorrow and profoundly impact health for humanity.

We are searching for the best talent for a Senior Manager, Biotherapeutics R&D, to be based on‑site in Spring House, PA. The Senior Manager will define and advance next‑generation immunotherapy design strategy, shape scientific direction, drive execution, and identify differentiated therapeutic opportunities grounded in deep biological insight and translational relevance.

• Own the scientific strategy and execution for next‑generation platforms across immunology, oncology, and adjacent disease areas.
• Lead multidisciplinary teams spanning discovery biology, protein design/optimization, translational sciences, computational biology, pharmacology, and therapeutic area expertise to advance programs from concept through candidate selection.
• Drive creation of novel therapeutic architectures that selectively recruit and program immune responses against disease‑driving biology.
• Define and implement molecular strategies that enhance therapeutic activity while regulating biological response and expanding therapeutic index.
• Translate advances in immunology, systems biology, synthetic biology, computational sciences, and protein engineering into actionable therapeutic opportunities and platform capabilities.
• Maintain end‑to‑end ownership of scientific decisions that influence molecule performance, differentiation strategy, and long‑term portfolio value.
• Identify and resolve critical biological and engineering bottlenecks affecting efficacy, safety, develop ability, and translational potential.
• Convert complex and ambiguous scientific questions into executable research strategies, measurable milestones, and portfolio decisions.
• Drive rapid hypothesis generation, experimental learning cycles, and evidence‑based decision‑making across programs.
• Mentor and develop high‑performing scientists while fostering a culture of scientific rigor, curiosity, accountability, and bold thinking.
• Build teams that challenge assumptions and pursue bold ideas while maintaining strong execution discipline.

• PhD, MD/PhD, or equivalent in immunology, cell biology, molecular biology, bioengineering, or a related discipline.
• At least 8+ years of relevant research experience in biotechnology, biopharma, or leading translational academic environments.
• Deep expertise in immune cell biology and mechanisms governing cellular activation, signaling, differentiation, and functional response.
• Demonstrated success advancing biologic therapeutics from discovery through candidate selection.
• Strong understanding of translational pharmacology, disease biology, and mechanisms of therapeutic differentiation.
• Proven ability to lead multidisciplinary scientific teams in complex, matrixed research environments.
• Experience with multispecific therapeutic modalities, immune‑engaging platforms, or engineered signaling systems (preferred).
• Expertise spanning multiple immune cell populations, including innate and adaptive immune biology.
• Experience in mechanistic assay development, human translational systems, and biomarker strategy.
• Strong publication, patent, and/or drug discovery track record.
• Demonstrated ability to translate frontier science into differentiated therapeutic opportunities and platform value.

• Ability to connect first‑principles biology with therapeutic design.
• Systems‑level thinking rather than target‑level thinking.
• Comfort operating where data are incomplete and scientific frameworks are still emerging.
• Ability to convert novel scientific concepts into scalable platforms and long‑term portfolio value.
• Curiosity to pursue important questions not yet fully defined by the field.

The future of medicine may…