Principal Scientist, Bioassay Methods Development
Job in
Malvern, Chester County, Pennsylvania, 19355, USA
Listed on 2026-08-01
Listing for:
Disability Solutions
Full Time
position Listed on 2026-08-01
Job specializations:
-
Research/Development
Research Scientist, Medical Science, Clinical Research, Data Scientist
Job Description & How to Apply Below
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.
Learn more at
As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.
Job Function:
Discovery & Pre-Clinical/Clinical Development
Job Sub Function:
Biotherapeutics R&D
Job Category:
Scientific/Technology
All Job Posting Locations:
Malvern, Pennsylvania, United States of America
Job Description:
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at
Johnson and Johnson is currently seeking a Principal Scientist, Bioassay Methods Development, located in Malvern, PA.
The Principal Scientist, Bioassay Methods Development, will be responsible for the development of cell-based bioassays and binding assays to be used as QC potency assays and in support of structure-function and biological characterization studies, to better understand mechanism of action for new molecular entities in clinical development and for commercial products. This role will also build and maintain strong relationships with Discovery partners to gain earlier insight into products entering development, increasing speed and facilitating readiness for cell-based assay development.
The individual will be accountable for method development, qualification, validation, and transfer activities as well as the evaluation of new technologies.
Key Responsibilities:
- Designing, troubleshooting, and executing experiments independently. Analyzing data, interpreting results, and reporting data in laboratory notebooks. Collaborate with partners to troubleshoot assay problems as they occur. Maintain awareness of the current literature relevant to methods.
- Establishing and strengthening partnerships with Discovery teams to understand emerging product attributes, anticipated assay needs, and development timelines, enabling earlier planning and readiness for cell-based assay development.
- Authoring protocols and reports. Performing and coordinating testing to support analytical development, manufacturing process development, process validations, and manufacturing investigations across functional groups.
- Accurately recording data in a timely manner, including maintenance of detailed records in compliance with applicable GMP, safety, and environmental requirements. The successful candidate will ensure data integrity and protocol compliance.
- Authoring and reviewing analytical sections of regulatory submissions (INDs, BLAs, MAAs).
- Providing technical support with development and QC laboratories is expected and the successful candidate will also support Quality Assurance, Regulatory Affairs and Process Development groups for all phases of product development as well as ongoing support of analytical methods for marketed products.
- Lead matrix teams, with potential responsibility for supervising 2-3 direct reports.
Education:
- A minimum of a Bachelor's degree in Biology, Pharmacology. Immunology, Biochemistry, or other relevant scientific fields, with at least 9 years of industry experience, a Master's degree with at least 7 years of industry experience, or a PhD with 4 years of relevant experience is required.
Required:
- Experience in development of bioassays, binding assays, and/or immunochemical…
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