Associate Principal Scientist, Mass Spectrometry

Job Title

The Analytical Enabling Capabilities organization in West Point, PA is seeking a motivated scientist with technical expertise in mass spectrometry-based protein, protein conjugation or oligonucleotides or polysaccharide characterization. In addition to mass spectrometry skills, we are also seeking candidates with strong scientific leadership, proteomics and data science skills.

The ideal candidate will have a track record of advancing the pharmaceutical development of vaccines with mass spectrometry, as well as driving scientific excellence through external presentations and publications. Additionally, the candidate will have advanced knowledge in both analytical experimental design and vaccines pipeline programs. Finally, this Associate Principal Scientist will be a partner in problem solving, building leadership, and driving collaboration both internally and externally.

• Develop and Perform LC-MS based assays including peptide mapping, intact mass, native mass spectrometry, proteomics, higher order structure, and host cell protein analysis or oligonucleotides or polysaccharide characterization for vaccines programs.
• Advance mass spectrometry methodology for peptide mapping, intact mass, native mass, HDX, sequence variants, glycan analysis, quantitative analysis, and host cell protein analysis.
• Represent the mass spectrometry group in project teams.
• Author technical reports and scientific presentations.
• Explore and develop new technologies to advance the field of mass spectrometry.
• Perform data processing with Genedata or other biopharma data interpretation software.
• Demonstrate effective multitasking, prioritization and problem-solving skills in the planning and execution of experiments.
• Scientific leadership and mentorship of scientists.
• Champion compliance and safety as a leader both within and outside the laboratory.

• PhD in Analytical Chemistry or Chemistry or relevant degree in mass spectrometry plus 5+ years of relevant experience in pharmaceutical industry
• Candidates with MS in degree plus 8+ years or BS degree plus 12+ years of relevant industry experience

• A breadth and depth of analytical and vaccines development understanding, including protein, protein conjugates, oligonucleotides and polysaccharides.
• Experience in conducting mass spectrometry experiments, including sample preparation and optimization, liquid chromatography separation, mass spectrometer operation and maintenance, data interpretation, and analysis.
• Extensive knowledge of Thermo, Sciex, Agilent and Waters instruments.
• Familiarity with Genedata or other biopharma MS software.
• Excellent verbal and written communications skills, as demonstrated through high impact scientific publications and presentations.
• Experience mentoring junior scientists in pharmaceutical development

• Expertise in multiple reaction monitoring based quantitative analysis for vaccines development.
• Expertise in complex glycan analysis.
• Familiarity with R programming language for data processing, statistics and visualization.
• Advanced knowledge of electronic laboratory notebook applications and good documentation practices.

Analytical Chemistry, Analytical Method Development, Assay Development, Biological Assay Development, Cell-Based Assays, Chromatographic Techniques, High Resolution Mass Spectrometry (HRMS), Laboratory Documentation, Liquid Chromatography-Mass Spectrometry (LC-MS), Mass Spectrometry (MS), Mass Spectrometry Analysis, Peptide Mapping, Process Analytical Technology (PAT), Protein Analysis, Proteomics, R Programming, Secondary Ion Mass Spectrometry (SIMS), Spectrometry, Vaccine Development

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