Principal Scientist, Toxicology

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Discovery & Pre-Clinical/Clinical Development

Nonclinical Safety

Scientific/Technology

Spring House, Pennsylvania, United States of America

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We are searching for the best talent for a Principal Scientist, Toxicology in Spring House, PA.

Purpose:

This Principal Scientist in Nonclinical Safety and Submissions, a department in the Preclinical Sciences and Translational Safety (PSTS) organization within Johnson & Johnson Innovative Medicine, supports nonclinical safety evaluation in late discovery and development for various therapeutic areas.

• Design of in vivo general toxicology studies for biologics, small molecules, and other modalities.
• Integrated scientific data interpretation and critical report review for general toxicology and safety pharmacology studies.
• Oversee and monitor contracted in vivo toxicology and in vitro/in vivo safety pharmacology studies in compliance with Good Laboratory Practices (GLPs) and animal welfare regulations, following company policies and standard operating procedures.
• Engagement in multi-disciplinary teams within PSTS and close collaboration with nonclinical project representatives to provide scientific and technical expertise on drug development programs.
• Participate in issue-resolution teams through active engagement in scientific discussions and the shaping of strategies designed to support and inform critical development decisions.
• Provide strong scientific input regarding potential mechanisms of toxicity in molecular pathways and propose appropriate follow-up. Maintain up-to-date knowledge regarding innovative approaches in toxicological research.
• Work independently, foster constructive cross-functional collaborations with both internal and external partners, and be able to prioritize workload in alignment with pipeline priorities.
• Adhere to timelines; proactively identify and communicate study-related issues and develop contingency plans.
• The candidate will contribute to the success and growth of PSTS through active participation in internal and external committees / working groups and will closely interact with scientists in other functional areas including pathology, bioanalysis, toxicokinetics, and development project leaders in the US, Belgium, and China.

• Minimum of Master’s Degree in biomedical sciences, toxicology, pharmacology, or similar education is required;
  PhD is preferred.

• A minimum of 5 years of relevant experience is required.
• Experience as a Study Director or Study Monitor conducting/overseeing in vivo toxicology studies supporting projects in discovery through development is required
• Knowledge of major species typically evaluated as toxicology models is required
• Knowledge in immunology or immunotoxicology is preferred.
• Strong written and verbal communication skills and the ability to negotiate and influence…