Senior Principal Scientist, Biologics Discovery Process Research Integrator

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Discovery & Pre-Clinical/Clinical Development

Biotherapeutics R&D

Scientific/Technology

Malvern, Pennsylvania, United States of America, Spring House, Pennsylvania, United States of America

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We are searching for the best talent for a Senior Principal Scientist, Biologics Discovery Process Research (BDPR) Integrator to be located in Spring House, PA or Malvern, PA.

The Senior Principal Scientist, will serve as the scientific and strategic connection point between Therapeutic Development & Supply (TDS) and Discovery teams, enabling seamless end-to-end decision-making for biologics programs. This role is deeply technical and focuses on proactively identifying and mitigating development risks during the discovery phase. The leader will ensure that structural, biophysical, expression, and develop ability insights are assessed and effectively integrated into Chemistry, Manufacturing and Controls (CMC) strategies and program planning.

Additionally, the leader will be tasked with identifying early opportunities to assess knowledge gaps to derisk program development. The preferred candidate brings deep scientific expertise in protein structure and develop ability, strong understanding of CMC development requirements, and a proven ability to influence without authority while navigating complex cross-functional environments.

• Serving as the BDPR integrator on Discovery project teams, aligning strategy, data expectations, and technical risk assessment across Discovery and Development.
• Providing deep scientific guidance on molecule selection, engineering, develop ability, manufacturability, expression, and protein structure-function considerations.
• Identifying and mitigating CMC, technical, operational, and manufacturability risks early, translating findings into clear program recommendations and mitigation plans.
• Ensuring continuity of scientific rationale and technical context as programs advance from Discovery through candidate nomination and IND-enabling activities.
• Building trusted cross-functional partnerships and influencing decision-making across Therapeutics Discovery (TD), Preclinical Sciences & Translational Safety (PSTS), Therapeutic Areas (TAs), and TDS in matrixed governance and technical forums.

• PhD in Structural Biology, Biochemistry, Biophysics Chemical or Biomedical Engineering, or a closely related field is required.

• A minimum of 10 years of biopharmaceutical R&D experience spanning both Discovery and Development / CMC functions.
• Deep technical expertise in at least one of the following areas: protein structure, develop ability principles, and expression considerations and the impact these have on CMC development.
• Strong understanding of end-to-end biologics development, including the scientific and operational needs of CMC.
• Proven ability to…