Senior Scientist – Lentiviral Vector Upstream Process Development

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

Learn more at

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Discovery & Pre-Clinical/Clinical Development

Biotherapeutics R&D

Scientific/Technology

Spring House, Pennsylvania, United States of America

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

Learn more at  We are searching for the best talent for a Senior Scientist – Lentiviral Vector Upstream Process Development to be based in Spring House, PA.

The Senior Scientist, Lentiviral Vector Upstream Process Development, will lead development, optimization, and characterization of scalable cell culture processes for cell therapy and CAR-T programs. This role will provide scientific leadership for early- or clinical-stage process development, with emphasis on cell culture and bioreactor execution at varying scales and data-driven process understanding, platform robustness and knowledge and optimization of upstream process technologies.

This role will also support technology transfer to Johnson & Johnson’s manufacturing sites, commercial manufacturing investigations and provide subject matter expert knowledge as part of life cycle management for cell therapy products in Johnson & Johnson’s pipeline.

• Design and execute upstream process development studies for lentiviral therapeutic products and provide scientific guidance.
• Conduct cell culture experiments using shake flasks, bench-scale bioreactors, and automated high-throughput systems.
• Contribute to development of lentiviral processes to continuously improve productivity, quality, and manufacturability.
• Perform technology transfer to and collaborate with Johnson & Johnson’s manufacturing sites
• Support existing and new commercial manufacturing investigations and provide subject matter expert knowledge as part of product life cycle management
• Apply statistical experimental design, data analytics, and online monitoring and visualization tools to strengthen upstream process understanding.
• Analyze and interpret process data using JMP, Mini Tab, Python, Spotfire, or similar platforms.
• Evaluate emerging novel upstream technologies that improve process robustness and development efficiency.
• Collaborate closely with downstream, analytical, formulation, modeling, automation to align study design and deliverables
• Mentor junior scientists and provide scientific leadership across programs and cross-functional work streams.
• Author technical reports, development summaries, scientific presentations, protocols, and regulatory-supporting documentation.

• PhD in Chemical Engineering, Biochemical Engineering, Biological Sciences, Biotechnology, or related field with 2+ years of relevant experience; OR BS or MS with 4-6 years of relevant experience.
• Experience with process development of viral based products.
• Experience in mammalian cell culture process development for biologics, cell and gene therapy, RNA therapeutics, or…