Senior Scientist, Biologics Design and Function

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

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Spring House, Pennsylvania, United States of America

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

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We are searching for the best talent for a Senior Scientist, Biologics Design and Function to be located in Spring House, PA.

The Biologics Design & Function team within Biologics Discovery is responsible for translating biological insights into differentiated therapeutic strategies and functional outcomes across biologic modalities. We address complex scientific questions and solve novel challenges with creativity, calculated risk taking, and a multi-disciplinary, collaborative spirit.

We are seeking a highly motivated Senior Scientist to help define, evaluate, and advance innovative therapeutic concepts that use the immune system to treat disease. This individual will combine deep expertise in immune cell biology with hands-on laboratory experience to investigate therapeutic mechanisms of action, establish functional differentiation, and evaluate molecule optimization across a diverse discovery portfolio.

This role requires scientific curiosity, strong problem-solving skills, and a passion for addressing complex biological questions. The successful candidate will collaborate closely with protein engineers, computational scientists, drug discovery teams, and therapeutic area scientists to generate mechanistic insights that drive therapeutic innovation. The position provides the opportunity to contribute directly to discovery programs while developing scientific leadership capabilities through participation on multidisciplinary project teams and strategic discovery initiatives.

• Designing, implementing, and interpreting mechanistic and functional studies that guide molecule design, establish therapeutic differentiation, and inform program decisions.
• Serving as subject matter expert to apply immunological and biological insights to guide molecule optimization and inform key discovery-stage decisions.
• Developing and implementing innovative assays, experimental approaches, and technologies that enhance understanding of therapeutic mechanisms and biological function.
• Evaluating emerging technologies and developing innovative approaches to accelerate biologics functional assay workflows and therapeutic discovery.
• Demonstrating abilities to solve complex biological problems and translate mechanistic insights into actionable therapeutic strategies.
• Independently communicating scientific findings through presentations, technical reports, patent applications, publications, and project team discussions.
• Contributing to a culture of scientific excellence, innovation, collaboration, and continuous learning.

• A minimum of a Master's degree in Immunology, Cell Biology, Biochemistry, Bioengineering, or a related scientific field is required. A PhD is highly preferred.

• 4+ years of industry experience with a Master's degree; 2+ years of experience with a PhD.
• Deep understanding of immunology, disease biology, and mechanisms governing immune cell signaling, activation, differentiation, and functional responses.
• Demonstrated experience advancing biologic therapeutics and discovery programs in complex research environments.
• Expertise in designing, developing, and interpreting mechanistic cellular assays, particularly using primary human immune innate and adaptive cells.
• Proven ability to influence multidisciplinary teams and work effectively within matrixed organizations.
• Excellent written and verbal communication skills.

• Experience advancing multispecific antibodies, immune-engaging therapeutics, or other complex biologic modalities through key discovery-stage decisions.
• Demonstrated success developing innovative…