Scientist – Lentiviral Vector Downstream Process Development

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

Learn more at

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Discovery & Pre-Clinical/Clinical Development

Biotherapeutics R&D

Scientific/Technology

Spring House, Pennsylvania, United States of America

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

We are searching for the best talent for a Scientist – Lentiviral Vector Downstream Process Development to be based in Spring House, PA.

The Scientist, Lentiviral Vector Downstream Process Development, will lead development, optimization, and characterization of scalable purification processes for cell therapy and CAR-T programs. This role will contribute to early- or clinical-stage process development, with emphasis on purification process strategy at varying scales and data-driven process understanding, platform knowledge and robustness, and optimization of downstream process technologies. This role will also support technology transfer to Johnson & Johnson’s manufacturing sites, commercial manufacturing investigations and provide subject matter expert knowledge as part of life cycle management for cell therapy products in Johnson & Johnson’s pipeline.

• Design and execute downstream process development studies for lentiviral therapeutic products under scientific guidance
• Conduct purification experiments including chromatography, filtration, UF/DF, and formulation, and automated high-throughput systems
• Contribute to development of lentiviral processes to continuously improve productivity, quality, and manufacturability.
• Oversee operation and management of downstream equipment, including AKTA systems, TFF systems, and purification skids.
• Perform technology transfer to and collaborate with Johnson & Johnson’s manufacturing sites
• Support existing and new commercial manufacturing investigations and provide subject matter expert knowledge as part of product life cycle management
• Apply statistical experimental design, data analytics, and online monitoring and visualization tools to strengthen downstream process understanding.
• Analyze and interpret process data using JMP, Mini Tab, Python, Spotfire, or similar platforms.
• Evaluate emerging novel downstream…