Senior Scientist, Structural Biology

Role

Senior Scientist in Structural Biology focused on accelerating therapeutic discovery through high-impact structural studies.

• Responsibilities include purifying and characterizing antibodies, antigens, and complexes
• preparing cryo-EM samples, processing data, and interpreting structures to inform antibody design and optimization
• utilizing complementary techniques like crystallography and biophysical methods
• maintaining detailed records, troubleshooting workflows, and collaborating with cross-functional teams in biologics, protein sciences, and biophysics.

• PhD in Structural Biology, Biochemistry, or Biophysics with 2+ years postdoctoral or industry experience
• expertise in antibody-antigen structural biology, cryo-EM, protein expression, purification, and complex assembly
• proficiency with cryo-EM software and structural analysis tools
• strong collaboration, communication, and problem-solving skills.

• experience with negative-stain EM, crystallography, antibody discovery, and structure-guided design
• evidenced impact on drug discovery projects through published structures.

focus on biologics, antibody complexes, cryo-EM, structure-based drug design, and collaborative cross-disciplinary research.

located in Spring House, PA; specific travel requirements not detailed.