Liver Cancer and Ultrasound Imaging Postdoc Fellowship
Listed on 2026-09-15
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Research/Development
Research Scientist -
Healthcare
University of Pennsylvania:
Postdoctoral Positions:
Perelman School of Medicine Postdoctoral
University of Pennsylvania – Perelman School of Medicine
Open Date:
Aug 10, 2026
Chandra Sehgal, PhD
Hiring DepartmentRadiology
Funding SourceNIH
Number of positions1
U.S. Citizens and foreign nationals may apply
Project OverviewThe ultrasound research lab is developing hydralazine-augmented contrast ultrasound (HyCUS), a novel functional imaging technique that exploits differences in tumor versus liver vasculature to improve early detection of hepatocellular carcinoma (HCC), the fastest-growing cause of cancer death in the U.S. Our preliminary data show HyCUS more than triples lesion visibility compared to standard B-mode and contrast-enhanced ultrasound, and detects small HCC lesions missed entirely by current clinical methods.
We are seeking a motivated postdoctoral fellow to help translate this promising discovery from bench to bedside.
The candidate will lead validation studies in an autochthonous rat model of HCC with liver fibrosis, working across three interconnected aims: establishing the biological basis of HyCUS, defining an optimal hydralazine dosing regimen, and benchmarking HyCUS against existing sonographic surveillance methods. The investigator will work at the intersection of cancer biology, vascular pharmacology, and noninvasive imaging. The position provides an opportunity to shape a translational imaging technology from preclinical proof of concept toward eventual clinical application.
Qualifications- PhD, MD/PhD, or equivalent doctoral degree in Biomedical Engineering, Bioengineering, Chemical Engineering, Pharmacology, Imaging Sciences, or a related field.
- Background and interest in tumor biology, vascular physiology, or pharmacology
- Hands-on experience with animal models and histology is required
- Interest in contrast-enhanced ultrasound imaging
- Strong analytical and writing skills; interest in building an independent research trajectory
We will provide training in any missing technical skills for motivated candidates.
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