Principal Scientist, Biologics Optimization

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Job Function:
Discovery & Pre-Clinical/Clinical Development

Job Sub Function:
Biotherapeutics R&D

Job Category:
Scientific/Technology

All Job Posting Locations:
Spring House, Pennsylvania, United States of America

About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at

We are searching for the best talent for Principal Scientist, Biologics Optimization in Spring House, PA

Purpose:

The Biologics Optimization team within Biologics Discovery is responsible for the design and optimization of lead biologic variants across multiple therapeutic modalities to achieve differentiated functional outcomes aligned with desired therapeutic mechanism of action (MoA). In this position, the Principal Scientist will serve as a scientific leader and subject matter expert in biologics optimization, driving and dissecting protein engineering strategies that translate molecular design into improved biological function across diverse therapeutic modalities.

This role requires deep expertise in antibody and protein engineering, computational and AI/ML-enabled design approaches, and mechanism-driven biologics discovery expertise. The Principal Scientist will provide scientific leadership in function-based biologics optimization, translating therapeutic mechanisms of action and molecular design insights into differentiated functional outcomes across diverse therapeutic modalities. This role will drive the design and delivery of fit-for-purpose optimized protein sequences and evaluate critical attributes-including biological function, potency, selectivity, production, and develop ability-using display technologies, structure- and modeling-guided design, and emerging computational and AI/ML approaches.

The successful candidate will partner closely with Therapeutic Area scientists, computational scientists, protein engineers, and drug discovery teams to develop and implement optimization strategies that enhance potency, selectivity, efficacy, and overall therapeutic performance. This role offers an exciting opportunity to not only engage in the discovery and molecular engineering of biotherapeutics, but to develop new processes and technologies in collaboration with other functional group with the opportunity to lead project teams and interact with world-class Therapeutic Area scientists.

• Lead biologics optimization efforts across multiple therapeutic programs, translating target biology and desired mechanisms of action into rational protein engineering strategies.
• Serve as a subject matter expert in function-driven optimization: develop…