Principal Scientist, Protein Purification, Team Lead

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow,and profoundly impact health for humanity.

Learn more at

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow,and profoundly impact health for humanity.

Learn more at

Discovery & Pre-Clinical/Clinical Development

Biotherapeutics R&D

People Leader

Spring House, Pennsylvania, United States of America

About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at

We are searching for the best talent for Principal Scientist, Protein Purification, Team Lead in Spring House, PA.,

Purpose:

At Johnson & Johnson Biologics Discovery, we work in a fast-paced R&D environment applying rigorous scientific principles towards advancing groundbreaking protein therapeutics. In support of this mission, you will lead a team of scientists who deliver purified antibodies, multispecifics, and other therapeutic proteins for characterization and in vivo studies. Your group will combine purification science, process development, automation, and protein biochemistry to generate preclinical candidates and drive decision‑ready data.

As a partner across Discovery and Development, you will connect biological activity, manufacturability, and program strategy. You will set direction, build an inclusive and accountable culture, and guide technical decisions that advance the strongest leads. You will lead and develop a protein purification team at the center of biologics discovery. We are seeking an exceptional scientific ideator and empathetic people leader who can identify bold, practical solutions to discovery challenges, turn large and complex datasets into insight, and apply strong protein biochemistry expertise to advance therapeutic leads.

You will be responsible for:
Build and develop the team. Coach scientists, set clear expectations, provide useful feedback, and create an environment where people can grow, raise risks, and ideate. Drive lead-selection decisions. Partner with multidisciplinary project teams to define molecule‑quality strategies, interpret integrated data, manage trade‑offs, and advance therapeutic leads. Set purification strategy. Guide fit‑for‑purpose purification and process development for antibodies, multispecifics, and other recombinant proteins, including scalable handoff to development partners.

Apply technical judgment. Use deep knowledge of chromatography, FPLC, HPLC, protein quality, and analytical methods to balance purity, recovery, speed, scalability, and downstream needs. Improve how the work is done. Advance automation, digital tools, and data workflows…