Senior Scientist, Multiomics

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Discovery & Pre-Clinical/Clinical Development

Biological Research

Scientific/Technology

Cambridge, Massachusetts, United States of America;
Spring House, Pennsylvania, United States of America

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We are searching for the best talent for a Senior Scientist, Multiomics to be located in Cambridge, MA or Spring House, PA.

We are seeking an accomplished Senior Scientist to develop mechanistic insights from phenotypic assays that are based in spatial omics disease maps. The ideal candidate will lead the development of technically-complex, high‑throughput cellular assay platforms that support discovery efforts in immunology, neuroscience, and oncology. The ideal candidate must have deep expertise in designing and constructing genetic libraries, implementing CRISPR‑based perturbation strategies, and building engineered cell systems that enable mechanistic insights and scalable experimentation.

This role offers the opportunity to shape cutting‑edge experimental platforms that drive discovery and enable the systematic exploration of complex biological systems rooted in a deep, multimodal spatial understanding of disease biology.

In this role, you will design and execute complex phenotypic assays, including FACS‑based analyses, pooled optical screening, massively parallel reporter assays (MPRA), and other multiplexed readout approaches. You will deploy these assays across a range of primary and engineered cell types. Experience with immune cells and advanced model systems such as iPSCs, organoids, co‑culture systems, and cell‑printing technologies is highly valuable.

You will also drive innovation in the development of perturbation libraries, optimize their delivery and expression, and expand next‑generation cellular models to interrogate disease‑relevant biological pathways. A foundation in basic computational skills is essential to support library design, data exploration, quality control, and visualization, and close collaboration with computational colleagues will be integral to success in this role. The position will additionally require cross‑training in spatial omics technologies, with prior experience in this area highly preferred.

• Design, construct, and optimize genetic libraries for CRISPR-based perturbation, reporter assays, over‑expression systems and multiplexed functional studies.
• Develop and execute complex phenotypic assays, including high‑content imaging, pooled optical screens, and massively parallel reporter assays (MPRA).
• Engineer and characterize advanced cellular models, including an emphasis on immune cells and models relevant to immunology, neuroscience, and oncology.
• Establish and optimize FACS-based workflows, including sorting strategies, multicolor panel design, and high‑throughput cell processing.
• Implement and refine pooled and arrayed screening platforms, ensuring robust delivery,…