Scientist, In Vivo Process Development Downstream

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Job Description

The Scientist, In Vivo Process Development Downstream role designs and executes downstream/purification experiments to support development of manufacturing processes for Lentivirus.

This role applies advanced chemistry, biochemistry, and/or engineering principles to deliver robust, scalable processes, supports manufacturing activities and process optimization at scale, and operates with broad autonomy and limited oversight. The Scientist is accountable for end-to-end process performance, scientific soundness, and technical leadership while training and mentoring colleagues.

Key Responsibilities

* Design and optimize scalable, safe, and cost-effective downstream process for Lentivirus manufacturing.

* Develops technical solutions to complex problems requiring ingenuity and creativity, applying advanced scientific/engineering principles to ensure scientific soundness and performance.

* Supports manufacturing activities and process optimization at scale, contributing technical expertise to improve process performance and scalability.

* Manages day-to-day laboratory operations, including planning work, maintaining efficient lab execution, and ensuring effective documentation practices.

* Keep accurate, detailed laboratory records and comply to all required training and safety guidelines.

* Apply statistical methodologies and basic modelling approaches to design experiments, perform data analysis, and interpret data.

* Trains, guides, and mentors colleagues by sharing technical skills, coaching on process execution, and troubleshooting, and strengthening team capability.

* Communicates technical outcomes in technical reports and presentations

* Interface with multidisciplinary groups to solve complex issues and promote collaboration.

* Works independently with broad autonomy and limited oversight; determines approaches for moderately complex assignments under minimal direction.

Education and Experience

* B.S., M.S, PhD/Pharm

D in science or engineering

* BS with 6+ years post-graduate relevant experience in bioprocess/biotechnology, or

* MS with 4+ years post-graduate relevant experience in bioprocess/biotechnology, or

* PhD/PharmD

Required Qualifications

* Must have strong scientific understanding and demonstrated hands-on proficiency of downstream unit operations for large biomolecules (e.g. protein, virus) such as chromatography and filtration.

* Sound understanding of bioprocess scale-up principles for large biomolecules

* Working knowledge of cGMP principles

* Proficiency in Microsoft Word, Excel, Power Point, and data analysis software such as JMP, Graph Pad

* Proven ability to collaborate in a dynamic team environment

* Excellent interpersonal, verbal, and written communication skills

* Strong organization and problem-solving skills with excellent attention to details

Preferred Experience and Skills

* Prior experience with process development of viral vectors

* Prior experience with the use of Design of Experiments (DOE) to support process development experiments.

* Prior experience with fermentation/cell culture and analysis of large biomolecules

* Hands-on experience with large scale bioprocessing in either non-GMP or GMP setting

* Demonstrated mentorship and team leadership

The salary range for this position is: $ - $. Kite considers a variety of factors when determining base…