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Executive Director, Early-Stage Clinical Development, Oncology

Job in Philadelphia, Philadelphia County, Pennsylvania, 19117, USA
Listing for: Immunocore
Full Time position
Listed on 2026-02-12
Job specializations:
  • Healthcare
    Healthcare Management
Salary/Wage Range or Industry Benchmark: 125000 - 150000 USD Yearly USD 125000.00 150000.00 YEAR
Job Description & How to Apply Below
Job Details:
Executive Director, Early-Stage Clinical Development, Oncology

Full details of the job.

Vacancy Name: Executive Director, Early-Stage Clinical Development, Oncology

Vacancy No: VN616

Employment Type: Full Time

Location of role: Gaithersburg, MD, US,
Conshohocken, PA, US
Oxford, UK

Department: Clinical Development

Key Responsibilities

The Executive Director, Early-Stage Clinical Development, Oncology will drive assigned oncology programs from pre-clinical stages to proof of concept. They will also contribute to the development of infrastructure within Immunocore’s Clinical Sciences department by leading designated projects and work streams.

The successful candidate will spearhead Clinical Development strategic planning and be responsible for the design and medical oversight of assigned clinical studies. This includes protocol development, medical monitoring, medical data review, results interpretation, reporting, and regulatory submissions. Additionally, they will lead innovation in trial design, including the development of biomarker strategies.

The incumbent is expected to think strategically at both the program and enterprise levels, with the ability to analyze data, troubleshoot programs, and develop risk mitigation plans.

As a key in-house oncology disease expert for R&D, this role requires strong strategic leadership, advisory skills, and close collaboration with cross-functional teams whilst providing oversight, guidance, and mentorship to junior physicians leading early-stage clinical trials.

The Executive Director will interact with all levels of management, peers, and leaders from academic centers involved in key collaborations, as well as external stakeholders in the medical and scientific community and global regulatory authorities. The incumbent will work with outstanding people who together pioneer the research, development, and commercialization of bi-specific TCR therapies.

Experience and Knowledge

The ideal candidate is an MD or MD/PhD scientist with a clinical perspective, a track record of exceptional achievements in oncology therapy development and expertise in multiple disease areas. They have:

  • Thorough understanding of the early drug development process including experience contributing to key clinical documents (e.g., protocols, ICF, IB, DSUR, CRF), reviewing and interpreting clinical data.
  • A strategic and critical mindset with strong problem-solving and analytical skills, as well as a proven ability in designing innovative clinical trials that have supported successful regulatory filings.
  • Expertise in presenting key headline data with professional authority, anticipating and addressing questions/concerns from senior leadership in a governance setting.
  • Established links with the medical community globally and locally, with proven ability to develop close working relationships with opinion leaders.
  • Working knowledge of GCP, ICH, GDP and relevant CFRs is required; familiarity with MHRA, EMA, and CHMP regulations and guidelines and other international regulatory requirements is a plus.
  • Solid working knowledge of Microsoft applications such as Excel, Access, Word, and Outlook.
  • Leadership and Stakeholder Management

    Demonstrated ability to build mutually respectful relationships with colleagues, troubleshoot challenges and provide direction, guidance, and support to the team to achieve near-term goals.

    Ability to facilitate discussions and collaboration among groups with diverse technical expertise, gain alignment and progress decisions on moderate to high complexity issues.

    Capable of providing clear direction and holding teams accountable to deliver timely execution of objectives. Motivate and energize cross-functional team members to achieve aggressive goals.

    Strong oral and written communication skills, professional presence, and demonstrated ability to engage effectively with stakeholders at all levels including senior leaders.

    Foundational people management skills with the ability to oversee and manage the activities of junior physicians and clinical scientists, mentor colleagues, and bring the Immunocore vision and strategy to life for others at all levels.

    Education and…
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