Postdoc in nasal epithelial physiology and chronic rhinosinusitis

A postdoctoral position to study nasal epithelial physiology and signaling is available in the lab of Rob Lee  lab is part of the Division of Rhinology in the Department or Otorhinolaryngology, and we are also affiliated with and located next to the Department of Physiology. More about the lab's research and recent publications by postdocs and other students, can be found at  

Our primary disease interest is chronic rhinosinusitis (CRS), a syndrome of unrelenting nasal and sinus inflammation that affects >10% of the US population. We also study cystic fibrosis, a genetic disease that directly affects the innate immunity of both the lung and nasal epithelium. Our work is currently funded by both the NIH and the Cystic Fibrosis Foundation. Funding for this postdoctoral position will come from NIH/NIAID with a focus on modeling CRS using mouse nasal epithelial cells both in vitro and in vivo.

We are specifically interested in the role of bitter taste receptors (taste family 2 receptors or T2

Rs), which are expressed in the nasal epithelium and detect bitter bacterial products to stimulate innate immune responses (a review of this can be found at PMID: ). Bitter taste receptors are important in airway ciliated cells, important for mucociliary clearance and innate defense, as well as airway tuft cells, which drive epithelial inflammation. This project will use several unique mouse models to begin to better understand the role of taste receptors in CRS.

The postdoc will work closely with the PI and other lab members and receive training in live-cell imaging and other techniques as needed, potentially including measurements of calcium, nitric oxide, pH, ciliary beat frequency, fluid secretion, phagocytosis, and/or imaging of fluorescent protein biosensors. The postdoc will also be expected to independently or collaboratively develop or learn new techniques as required by the project.

Opportunities for professional development (grant writing, review writing, collaborations, conferences, etc.) will be encouraged and supported. Salary and benefit information and postdoctoral policies at Penn are outlined on the Penn Biomedical Postdoctoral Programs website (https://).

A PhD in a biological science (cell biology, biochemistry, molecular biology, immunology, physiology, etc.) with demonstration of successful completion of thesis project is required. Experience in cell culture, biochemistry, imaging, and/or in vivo mouse studies is highly desirable, but not required. Communication skills, enthusiasm, and good interpersonal skills are essential. We strive to create a collegial and professional team environment.

Please upload a cover letter, CV, and names of at least two references into Interfolio. Questions can be directed to (Use the "Apply for this Job" box below).

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.