Clinical Research, Project Manager; PHX, FWD or PIT

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Castle Biosciences Inc. is growing, and we are looking to hire a Clinical Research, Project Manager working from our Friendswood, TX, Pittsburgh, PA or Phoenix, AZ, office location, with a start date prior to April 15, 2026.

• Exceptional Benefits Package:
• Excellent Annual Salary + Bonus Potential
• 20 Accrued PTO Days Annually
• 10 Paid Holidays
• 401K with 100% Company Match up to 6%
• 3 Health Care Plan Options + Company HSA Contribution
• Company Stock Grant Upon Hire

This position will act as a Clinical Research, Project Manager responsible for leading feasibility planning, site engagement, and project execution for clinical trials across multiple disease states. The role bridges early trial feasibility with long‑term site support and quality improvement to ensure trials are successfully launched and optimized. Key responsibilities include developing and implementing feasibility strategies to evaluate site capabilities, analyze trial designs, and recommend appropriate sites;

identifying, recruiting, and onboarding participating hospitals and health systems; and providing targeted education and training to sites and stakeholders. The Project Manager will oversee protocol start‑up, regulatory monitoring, and sponsor‑level implementation activities, collaborating with internal teams and external partners to meet project deliverables on time while communicating progress and challenges to leadership. They will also work closely with the Clinical Trial Liaison and Study Operations teams to strengthen study center engagement, improve patient enrollment, and ensure regulatory compliance, while maintaining expertise in assigned therapeutic areas across the company’s clinical portfolio.

• Bachelor’s degree or equivalent (health sciences field preferred), or registered nursing certification.
• 3-5 years of experience in clinical research, healthcare, or public health‑related programs.
• Strong project management skills.
• Superior organizational and time management skills, ability to manage multiple concurrent tasks, determine relative importance and prioritize accordingly.
• Strong medical or clinical research background.

• Please see the full success profile at the end of the job ad.

• Located in the FWD, PIT or PHX office.
• Occasional travel may be required for training or site visits; approximately 4 times per year for site visits but may be more.

• Monday‑Friday, 40 hours/week, exempt positions, working from the Friendswood, TX, Pittsburgh, PA or Phoenix, AZ office locations.

We truly appreciate your time. If this feels like the right opportunity for you, we’d love for you to complete our mobile‑friendly application. We’re excited to learn more about you and look forward to connecting soon!

All candidates must be legally authorized to work in the United States. Currently, Castle Biosciences does not sponsor H‑1B visas, OPT, or employment‑related visas.

At Castle, it all comes down to people. After all, disease doesn’t just happen – it happens to people. We believe that disease management and treatment decisions can be better informed through a person’s unique biology, which is revealed through the scientific rigor of our innovative, laboratory‑developed tests. We are committed to empowering healthcare providers and patients with the goal of improved outcomes.

Every employee at Castle has an impact on patient care, and we work to ensure that everyone finds their work to be both challenging and rewarding
. We behave with integrity and treat our colleagues with respect and kindness
. Our culture fosters an environment of trust, transparency, and collaboration
. We prioritize and encourage internal growth and professional development
.

Castle Biosciences is an equal opportunity employer as to all protected groups, including protected veterans and individuals with disabilities.

If you have a disability and you believe you need a reasonable accommodation in order to search for a job opening or to submit an online application, email Reasonable Accommodations

No third‑party recruiters, please