Vice President of Peptide Therapeutics

At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives.

We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?” That question drives everything we do.

But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose.

Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

Position Summary The VP of Peptide Therapeutics will build and lead the Company's peptide therapeutics function and be responsible for the strategic direction, portfolio leadership, organizational development, and advancement of peptide-based therapeutics intended to target clinically relevant genetic mutations. This role will oversee scientific strategy and execution across peptide therapeutic discovery, formulation development, candidate optimization, translational development, and portfolio management.

This position will work cross-functionally with research, molecular oncology, bioinformatics, translational medicine, clinical development, regulatory, quality, business development, and external partners to advance peptide-based drug candidates from concept through preclinical development. The VP will provide executive scientific leadership, establish long-term strategic priorities, oversee organizational growth, manage portfolio investment decisions, and ensure peptide therapeutic programs are aligned with Caris' broader precision medicine, therapeutic development, and business objectives.

Job Responsibilities Lead the strategic direction and execution of peptide therapeutic programs focused on targeting disease-associated mutations.

Oversee peptide design, synthesis strategy, formulation development, optimization, characterization, and candidate selection.

Direct the development of peptide-based drug candidates, including evaluation of potency, selectivity, stability, delivery, manufacturability, and translational relevance.

Partner with genomics, bioinformatics, molecular biology, oncology, and translational science teams to identify mutation-driven therapeutic opportunities.

Establish and manage workflows for peptide formulation, screening, lead optimization, and preclinical candidate advancement.

Evaluate emerging peptide drug discovery technologies, delivery platforms, conjugation strategies, and formulation approaches to enhance therapeutic performance.

Provide scientific oversight for internal teams, contract research organizations, academic collaborators, and external development partners.

Design and review studies supporting mechanism of action, pharmacology, pharmacokinetics, pharmacodynamics, safety, and early development planning.

Translate mutation biology and molecular profiling insights into actionable peptide therapeutic development strategies.

Build project plans, define milestones, manage timelines, assess risks, and communicate program progress to senior leadership.

Support intellectual property strategy through invention disclosure, patent review, and competitive landscape assessment.

Contribute to regulatory and quality documentation related to peptide therapeutic development, as applicable.

Build, scale, and optimize the peptide therapeutics organization through organizational design, workforce planning, succession…