Senior Scientist; DMPK

Position: Senior Scientist (DMPK)
.Our vision is to create a charity where everyone feels like they belong, benefits from and participates in, the work we do. We actively encourage applications from people of all backgrounds and cultures, in particular those from ethnic minority backgrounds who are currently under-represented.

We want to see every candidate performing at their best throughout the job application process, interview process and whilst  therefore ask you to inform us of any concerns you have or any adjustments you might need to enable this to happen. Please contact  or
** 0
* * as soon as possible. Unfortunately, we are unable to recruit anyone below the age of 18, so that we can protect young people from health & safety and safeguarding risks.
200 staff. Limitless Potential. One team. Cancer Research Horizons.
** Senior Scientist (DMPK)**£41,700 - £46,500 plus
** Department:
** Therapeutic Innovation, R&I  
*
* Reports to:

** Group Leader    
** Location**:
Babraham Research Campus, Cambridge (Hybrid - 3 days per week on-site)   
** Contract type:
** 1-year Fixed Term Contract  
** hours:
** Full time, 35 hours per week
** Closing date:
** Sunday 1st March 2026 23:55pm  
** Interview Date:
** Approximately week commencing 9th March  
** Interview process:
** 2 stage interview process, initial screening call via teams followed by on-site competency-based interview.
** At Cancer Research UK, we exist to beat cancer.
** We have an exciting, high-impact opportunity for a
** Senior Scientist
** to join us at Cancer Research Horizons (CRH) in Cambridge, on a 1-year fixed term basis.  As a Senior Scientist in
** DMPK**, you will play a key role in advancing both small- and large-molecule programs from lead optimization through candidate selection.

The successful candidate will apply deep technical expertise in pharmacokinetics, metabolism, and quantitative modelling to support the design and execution of translational strategies across therapeutic areas.

Reporting directly to the DMPK Group lead, you will work closely with the medicinal chemistry team and more widely with cross functional teams, seeking to accelerate novel therapies into clinical development.

The role would suit a Senior Scientist with a PhD or BSc/MSc with relevant industrial experience.  Good time management skills, a proven ability to form close and effective relationships with colleagues at all levels and excellent written and verbal communication skills are essential. Every role at CRH is united by a single mission: beating cancer sooner. We carry out work that matters—impacting patients, families, and the future of science.
** About Cancer Research Horizons
** As the world’s biggest medical research charity, we’ve helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.

We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK’s established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK’s world-class academic network, cutting edge technology platforms and clinical expertise to
1) Bring new treatments to patients faster and
2) Tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.
Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, and Newcastle University, you’ll be joining over 200 staff from both industrial and academic backgrounds, all dedicated to bringing forward the day we cure cancer and making real life impact.
* Design and execute DMPK strategies to advance discovery programs from LO through candidate selection, across both small molecule and large molecules
* Plan and oversee in vitro and in vivo DMPK work, including metabolite identification, assess species differences, recommend species selection for toxicity studies, toxicokinetic evaluation, and DDI risk assessment.
* Perform human PK and dose predictions using a range of methodologies (allometry, mechanistic PBPK,…