Researcher​/Scientist III, Department of Translational Cardiovascular Research Center; TCRC)(Phoenix

Position: Researcher/Scientist III, Department of Translational Cardiovascular Research Center (TCRC)(Phoenix)
Researcher/Scientist III, Department of Translational Cardiovascular Research Center (TCRC)(Phoenix)

Posting Number
req
26099

Department
COM Phx Trans Cardio Rsrch Ctr

Department Website Link
(Use the "Apply for this Job" box below)./

Location
Greater Phoenix Area

Address
Phoenix, AZ USA

Position Highlights

The University of Arizona College of Medicine - Phoenix (COM-P) is seeking a highly motivated candidate for the full-time position of Researcher/Scientist III in Dr. Tobias Jakobi's laboratory. The lab is focused on the interplay of different RNA species and their underlying functional networks in the heart. The successful candidate will contribute towards research and research-related service in the area of translational cardiovascular research.

The successful candidate should be organized, detail oriented, productive and be able to work independently as well as with others. The Postdoctoral candidate will benefit from the interaction with the diverse and interdisciplinary environment at the University of Arizona College of Medicine - Phoenix.

This position involves analyzing research hypotheses using controlled investigations, experiments and/or trials for research on cardiovascular disease using cell models of cardiac pathology, with a goal toward translating basic science findings to clinically viable potential therapeutics. The position is best suited for someone who is detailed oriented, conscientious, and able to follow instructions and have the ability to communicate in a clear, concise manner, both orally and in writing.

Visa sponsorship is not available for this positions.

Outstanding U of A benefits include health, dental, and vision insurance plans; life insurance and disability programs; paid vacation, sick leave, and holidays; U of A/ASU/NAU tuition reduction for the employee and qualified family members; retirement plans; access to U of A recreation and cultural activities; and more! The University of Arizona has been recognized for our innovative work-life programs. For more information about working at the University of Arizona and relocations services, please .

Duties & Responsibilities

Perform aspects related to cellular and molecular biology research that include, but are not limited to:

Next-Generation Sequencing (NGS) & Genomics

• Library Preparation:
  Execute end-to-end DNA and RNA library preparation workflows for both short-read (Illumina) and long-read (Oxford Nanopore) platforms.
• Sample Processing:
  Perform high-quality RNA/DNA isolation from diverse and challenging biological matrices, including human and mouse tissues and plasma.
• Exosome Analytics:
  Lead the isolation of exosomes and subsequent purification of exosomal RNA for downstream transcriptomic analysis.

Molecular & Cellular Biology

• Gene Expression Analysis:
  Conduct precise quantification of nucleic acids using qRT-PCR and protein expression via immunoblotting.
• Cellular Imaging:
  Perform immunocytofluorescence and comprehensive histological preparations, including tissue processing and advanced microscopy/imaging.

• Cell Culture Management:
  Maintain and manipulate primary cells and cell lines, including the culture, expansion, and directed differentiation of induced pluripotent stem cells (iPSCs); execute complex molecular cloning strategies to support functional studies.

Genetic Engineering & Viral Vectors

• Construct Design:
  Engineer sophisticated DNA expression constructs for functional genomics studies.
• Viral Production:
  Oversee the development, packaging, and purification of Adenoviral and Adeno-associated virus (AAV) vectors for efficient gene transfer and expression modulation.

Performs, and/or oversees data generation in experiments to ensure data integrity, quality control, and compliance.

Collects, analyzes, and interprets data. Prepares statistical and narrative reports.

Develop, plan, design, and conduct advanced, multi-disciplinary research. Review progress and evaluate results.

Formulate research methods, and develop or collaborate in the development of new techniques, methods, and equipment.

Recommend solutions for research methodology by interpreting principles and analyzing complex facts.

Develop and maintain detailed documentation of…