Principal Scientist, Translational Oncology – Single Cell and Spatial Genomics, Solid Tumors

Principal Scientist, Translational Oncology – Single Cell and Spatial Genomics, Solid Tumors

US Remote

We are seeking a Principal Scientist to serve as a translational and strategic leader within our Oncology research organization. This role sits at the crossroads of reverse translation, biomarker science, and cutting‑edge genomics technology — driving mechanistic insight from the clinic back into discovery to accelerate and de‑risk our oncology pipeline. The ideal candidate brings deep expertise in cancer biology, a track record of cross‑functional leadership in a pharma or biotech environment, and hands‑on experience building and deploying single‑cell and spatial omics capabilities.

• Drive discovery and translational projects in collaboration with AI and internal research teams with a primary focus on integrating scRNA‑seq and spatial biology into Natera’s research and early phase clinical studies.
• Leverage novel technologies to inform reverse and forward translation efforts as well as internal target discovery and validation projects.
• Design and execute lab‑based research programs that bridge clinical observations with mechanistic hypotheses, supporting asset progression and CDP expansion.

• Lead and contribute to a technology area team focused on single‑cell genomics and spatial omics, building out multiomics capabilities to support foundational models and RWD efforts.
• Partner with internal and external collaborators to establish, optimize, and deploy cutting‑edge platforms for translational applications.
• Serve as an internal expert and thought leader on emerging genomics technologies relevant to oncology drug discovery and development.

• Represent translational science on life cycle, RWD, and Bio Pharma BD teams.
• Collaborate with Clinical, Biomarker, Discovery, and Regulatory colleagues to shape clinical trial design and biomarker plans.
• Build and maintain external scientific partnerships and advisory relationships as appropriate.

• Lead and mentor a team of scientists and contractors, with a strong commitment to career development and scientific growth.
• Foster a collaborative, high‑performance team culture with clear goals and accountability.

• Ph.D. in Cancer Biology, Molecular/Cellular Biology, Immunology, Bioengineering, or a closely related field.
• 6+ years of experience post‑Ph.D. in oncology translational research within biotech or pharma, including demonstrated growth into senior or principal scientist roles.
• Deep scientific expertise in at least one of the following: cancer cell biology, tumor biology, single‑cell genomics, spatial transcriptomics, or multiomics platforms; experience building or scaling these capabilities in an organizational context is strongly preferred.
• Strong publication and/or patent record reflecting independent scientific contribution.
• Demonstrated experience leading cross‑functional programs and influencing without authority across Research, Clinical, and Biomarker teams.
• Prior experience managing and mentoring scientists at multiple career stages.
• Exceptional scientific communication skills; ability to synthesize complex data and present compellingly to diverse audiences.

US Remote: $171,900 - $214,950 USD (base salary). Actual compensation varies based on experience, qualifications, and internal equity considerations.

• Annual performance incentive bonus
• Long‑term equity awards
• 401(k) with company match
• Generous paid time off and company holidays
• Additional wellness and work‑life benefits

Natera is an Equal Opportunity Employer. All qualified applicants will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. Natera also considers qualified applicants regardless of criminal histories, consistent with applicable laws.

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