Research Technologist II

Job Summary and Responsibilities

As a Research Tech, you will perform standard laboratory procedures with some independence, under the general supervision of a PI or Research Technician. Your contributions are vital for efficient lab operations.

Every day you will execute experimental protocols, collect/record data, and maintain lab equipment. You may also perform complex procedures and provide guidance to students.

To be successful in this role, you will possess a strong foundation in lab techniques, meticulous attention to detail, and work effectively independently and collaboratively. Reliability, safety adherence, and a willingness to learn are key. Other primary responsibilities include:

• Receive process and manage biospecimens—including tumor tissue cerebrospinal fluid (CSF) and blood—in compliance with CLIA-regulated protocols
• Isolate cell‑free DNA from CSF and extract genomic DNA from tumor tissue and peripheral blood
• Isolate circulating cells from CSF and perform tissue dissociation for downstream applications
• Prepare single‑cell RNA sequencing libraries using the 10x Genomics platform from tumor and CSF‑derived cells
• Generate DNA sequencing libraries from tumor tissue blood and cell‑free DNA
• Maintain rigorous accurate documentation of experimental workflows in accordance with established protocols and regulatory standards
• Contribute to a collaborative research environment through participation in lab meetings seminars and journal clubs
• Keeps accurate records of studies conducted with minimal supervision.
• Performs basic data analysis and processing as required by senior laboratory personnel.
• Creates, maintains, and updates lab's internal procedure manuals.

The Ivy Brain Tumor Center is a pioneering non‑profit clinical research program dedicated to developing transformative therapies for patients with aggressive brain tumors. As a global leader in early‑phase neuro‑oncology trials the Center hosts the largest portfolio of Phase 0 studies for brain tumors worldwide. Our multidisciplinary team integrates clinical care translational science and precision medicine to accelerate the identification and development of first‑in‑class therapies.

We are seeking a highly motivated Research Tech II to join our translational neuro‑oncology research team. This role is ideal for an individual with strong laboratory experience who is capable of independently executing complex experimental workflows. The successful candidate will play a key role in advancing innovative liquid biopsy platforms to study pharmacogenomic response tumor evolution and disease progression.

• Bachelor’s degree in biological sciences or a related field
• Two (2) years prior experience in ar research, clinical, or other scientific environment
• Prior laboratory research experience with demonstrated proficiency in cell culture molecular biology techniques (e.g. PCR qPCR) and/or sequencing library preparation
• Strong analytical and problem‑solving skills with the ability to learn and execute new techniques independently
• Excellent attention to detail organization and time management
• Strong written and verbal communication skills

• Four (4) years of prior experience in a research, clinical, or other scientific environment
• Background in cell biology neuroscience or oncology
• Familiarity with CLIA‑regulated workflows and liquid biopsy methodologies
• Experience with single‑cell RNA sequencing and next‑generation sequencing platforms
• Additional Information:
  Two to three letters of recommendation may be requested