Research Associate II

Position Details

Position Information

Recruitment/Posting Title Research Associate II Job Category Staff & Executive - Research Support (Laboratory/Non-Laboratory) Department RBHS Overview

New Jersey's academic health center, Rutgers Biomedical and Health Sciences (RBHS) takes an integrated approach to educating students, providing clinical care, and conducting research, all with the goal of improving human health. Aligned with Rutgers University-New Brunswick and collaborating university wide, RBHS includes eight schools, a behavioral health network, and five centers and institutes that focus on cancer treatment and research, neuroscience, advanced biotechnology and medicine, environmental and occupational health, and health care policy and aging research.

Our faculty are teachers, clinicians, and scientists with unparalleled experience who advance medical innovation and provide patient care informed by the latest research findings. We offer an outstanding education in medicine, dentistry, pharmacy, public health, nursing, biomedical research, and the full spectrum of allied health careers.

Our clinical and academic facilities are located throughout the state-at Rutgers University-New Brunswick, including Piscataway; and at locations in Newark, Scotch Plains, Somerset, Stratford, and other locations. Clinical partners include Robert Wood Johnson University Hospital in New Brunswick, Newark's University Hospital in Newark, and other affiliates.

Through this community of healers, scientists, and scholars, Rutgers is equipped as never before to transform lives.

Posting Summary

Rutgers, The State University of New Jersey is seeking a Research Associate II for the Pharmacology Department in the Center for Advanced Biotechnology and Medicine (CABM) of Rutgers Biomedical and Health Sciences (RBHS).

The primary purpose of the Research Associate II is to be responsible for the conduct of highly specialized and technical research on the topic of exploiting metabolic vulnerabilities in cancer. The Valvezan Laboratory studies how metabolic networks are coordinated to promote cell growth, and how to leverage that understanding to exploit metabolic dependencies in cancer. We discovered a targetable metabolic vulnerability that is induced downstream of mTORC1 in cancer, and can be exploited using clinically approved therapeutics to selectively kill cancer cells that have uncontrolled mTORC1 activation.

Research Associate II will work to determine the full translational potential of this potent vulnerability in human cancers. The Research Associate II will work at the interface of basic and translational science, combining genetic, pharmacological and molecular biology/biochemistry approaches with the latest metabolomics, metabolic flux analysis, and expression profiling assays in cultured cells and mouse tumor models to gain a comprehensive understanding of how signaling pathways remodel cellular metabolism and how to leverage these insights for therapeutic benefit.

Among the key duties of this position are the following:

* Performs various research and technical operations on the topic of exploiting metabolic vulnerabilities in cancer. Conducts research independently or as assigned specialized research for a particular project.

* Participates in the design and execution of experiments in cultured cells and mice to study signaling and/or metabolism in cell growth and cancer.

* Performs standard cell and molecular biology techniques including PCR, qPCR, gel electrophoresis, western blotting, immunofluorescence, immunohistochemical staining, cell growth and viability assays, flow cytometry.

* Keeps detailed records of procedures and experiments. Compiles data and presents findings.

* Prepares scientific manuscripts for publication, and contributes to the preparation of research grant and fellowship applications.

* Works independently as well as collaboratively, with a strong work ethic and attention to detail.

* Participates in the development of performance standards, selection of methodology and instrumentation and coordination of the analytical, biochemical, physiology and instrumentation functions with the research…