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Lead Integration Engineer

Job in Pittsburgh, Allegheny County, Pennsylvania, 15201, USA
Listing for: System One Holdings, LLC
Full Time position
Listed on 2026-07-14
Job specializations:
  • Engineering
    Systems Engineer, Automation & Mechatronics Engineer
Job Description & How to Apply Below

Lead Integration Engineer

Join a cutting-edge lab to discover novel therapeutics that are seeking a highly motivated Lead Engineer to support the integration, optimization, and operation of complex fluidic and instrumentation systems for advanced human-relevant experimental platforms. This role focuses on system-level design and implementation of fluid handling architectures, ensuring reliable, reproducible, and physiologically relevant operation across single- and multi-component platforms. The position will contribute to development of robust, scalable systems that integrate mechanical, fluidic, and control elements to support standardized experimental workflows.

Responsibilities:

  • Design, develop, and optimize fluidic systems, including manifolds, tubing layouts, and pump-controlled flow networks
  • Implement stable, leak-free circulation systems with controlled and reproducible flow profiles across experimental platforms
  • Support development of physiologically relevant flow conditions, including continuous and directional flow regimes
  • Integrate fluidic systems with broader experimental platforms, including device interfaces, instrumentation, and control systems
  • Contribute to system-level architecture design, coordinating fluidic, mechanical, and sensing components
  • Develop and implement control strategies for pumps, valves, and fluid routing systems
  • Perform system testing, validation, and troubleshooting to ensure operational reliability and consistency
  • Maintain detailed documentation of system configurations, standard operating procedures (SOPs), and performance validation
  • Collaborate with multidisciplinary teams to align system functionality with experimental and operational requirements
  • Contribute to improvement of system robustness, usability, and scalability for sustained and repeatable operation

Requirements:

  • Bachelor's degree in Mechanical Engineering, Electrical / Systems Engineering, or a related field
  • Minimum of 3 years of relevant experience in fluid systems, instrumentation, or experimental platform development
  • Experience with fluid handling systems, pumps, tubing, or flow control architectures
  • Experience with system integration and hardware-based experimental platforms
  • Strong analytical, troubleshooting, and problem-solving skills
  • Ability to work effectively in multidisciplinary research and engineering environments

Preferred Qualifications:

  • Master's or Ph.D. in a relevant engineering discipline
  • Experience with microfluidics, perfusion systems, or biologically relevant flow systems
  • Familiarity with control systems, sensors, and automated or semi-automated fluid handling platforms
  • Experience with design and implementation of complex, multi-component systems
  • Experience with data acquisition, monitoring systems, or system diagnostics
  • Experience working at the interface of engineering and biological systems
  • Experience in controlled or regulated laboratory environments
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