Senior Scientist, Transporters and In Vitro Technologies

Senior Scientist (Transporter Science Group)

• Design, execute, and integrate transporter-related in vitro and preclinical studies supporting drug discovery and development.
• Generate high-quality in vitro transporter data and support project teams across therapeutic areas.
• Develop and apply innovative in vitro/preclinical models and translational strategies to quantitatively predict transporter-mediated ADME, drug-drug interactions (DDIs), efficacy, toxicity, and enzyme-transporter interplay.
• Collaborate across the DMPK network and with partners in Medicinal Chemistry, Biology, Data Science, Clinical Research, and Toxicology.

• PhD (or equivalent) in a relevant field (Pharmaceutical Sciences, Pharmacology, Biochemistry, Biology) with 2–5+ years relevant experience.
• OR MS (or equivalent) with 8–10+ years relevant experience.

• In vitro drug transporter studies (substrate phenotyping and inhibition assays) using recombinant cell lines, vesicles, primary hepatocytes, or comparable systems.
• Cell culture and execution of experiments per established protocols; ability to design novel experiments.
• Data analysis (e.g., Graph Pad Prism) and strong interpretation.
• Prepare high-quality reports for regulatory submissions.
• Knowledge of drug transporters, pharmacokinetic principles, enzyme kinetics, and mechanistic DDIs.
• Strong written/oral communication; independent work with guidance; mentor/guide junior scientists.

• In vitro transporter kinetic studies and extrapolation to quantitative prediction of transporter-mediated disposition and DDIs.
• Mechanistic modeling using in vitro data; ADME knowledge for small molecules; critical review of transporter/ADME literature.
• Basic radiometric or LC/MS quantitation knowledge.

Apply via  (or Workday Jobs Hub). Requisition : R398825.