Senior Automation Engineer – Automation

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work-but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

The Senior Automation Engineer – Central Automation serves as the site Subject Matter Expert (SME) for the integration of automated manufacturing processes, data exchange, and centralized management of production information across the LKC automation architecture. This role is distinct from Process Engineering, which owns the design, programming, and troubleshooting of PLC, SCADA, and HMI applications at the equipment/process level. The Central Automation SME instead owns the layer that connects and orchestrates those systems: the flow of recipes, parameters, cycle and batch data, material and process identification, and material handling automation across the site network, ensuring that physical processes and data exchange occur in a consistent, automated, and compliant manner from the plant floor up through site and enterprise systems.

Key Objectives/Deliverables:

• Own the integration architecture connecting shop-floor control systems (PLC/SCADA/HMI, owned by Process Engineering) with site-level automation and business systems (MES, historian, LIMS, QMS, ERP interfaces)
• Design, configure, and maintain data exchange interfaces (OPC UA, MQTT, web services, database interfaces) between control systems and central platforms
• Serve as the technical owner for recipe management, parameter master data, and centralized batch/cycle report generation and distribution
• Ensure consistency and integrity of process and material data as it moves across integration layers

• Administer and optimize the site data historian (e.g., OSI PI or equivalent), including tag architecture, data contextualization, and retention strategy
• Support data analytics and reporting initiatives by ensuring clean, structured, and accessible process data
• Partner with Data Analytics/IT teams to enable dashboards, trending, and KPI reporting from integrated data sources
• Maintain data integrity compliance (21 CFR Part 11, ALCOA+) across all integrated data flows

• Serve as SME for the integration of automated material handling systems (AS/RS, AGVs/AMRs, conveyors, automated warehouse/logistics systems) with production and business systems
• Own the integration of process and material identification systems (barcode, RFID, vision-based ) into the site's data and tracking architecture
• Ensure seamless, automated data exchange between material movement/storage systems and MES/ERP for traceability and genealogy

• Act as site SME for Central Automation integration topics, providing technical guidance to Process Engineering, Manufacturing, and IT/OT teams
• Support investigations, root cause analysis, and change controls related to system integration and data flow issues
• Develop and maintain technical documentation (functional specifications, data flow diagrams, interface control documents) for integrated systems
• Support computer system validation (CSV) activities for integration platforms and data historian systems
• Represent Central Automation integration…