Senior IT Operations Manager - Pleasanton, CA

Calyxo, Inc. is a medical device company headquartered in Pleasanton, California, USA. The company was founded in 2016 to address the profound need for improved kidney stone treatment. Kidney stone disease is a common, painful condition that consumes vast amounts of healthcare resources each year. Our team is led by executives and investors with a proven track record of commercializing paradigm-shifting devices to meet unmet needs within urology.

Are you ready to change the future of kidney stone treatment? We are seeking high achievers who want to be part of a dynamic team working in a fun, diverse atmosphere.

Calyxo is seeking an experienced Senior IT Operations Manager to own the infrastructure backbone of the company as we scale toward and through IPO. This role leads day-to-day IT operations, ensuring reliable, secure, and responsive technology services that support Calyxo's employees and business objectives. You will own our enterprise network and endpoint infrastructure - including switching, firewall, and wireless environments - and will be the operational lead for our core security tooling stack (endpoint detection and response, security awareness training, and endpoint/cloud security).

You will also establish company-wide software license tracking, author and maintain IT policies and procedures, and own SOX testing and evidence management for IT general controls as Calyxo builds a public-company-grade control environment. As the team scales, this role will eventually take on oversight of the helpdesk/end-user support function.

This is a foundational, build-oriented role - you will inherit a growing environment and be responsible for hardening it, documenting it, and scaling it to support a ~500-employee pre-IPO medical device company.

• Own the design, deployment, and ongoing administration of Calyxo's network infrastructure, including enterprise-grade switches, firewalls, and wireless access points across HQ and manufacturing sites.
• Monitor network performance, capacity, and uptime; troubleshoot and resolve complex connectivity, routing, and security issues.
• Lead infrastructure and network build-out for new and expanding facilities (e.g., the Rosewood manufacturing site), including physical security and building management system integration.
• Maintain server, storage, and cloud infrastructure supporting business operations, in partnership with the broader IT team.

• Serve as the operational owner of Calyxo's core security tooling stack, including security awareness training and phishing simulation, endpoint detection and response (EDR), and endpoint/cloud security platforms.
• Monitor security alerts and incidents, drive remediation, and continuously improve the company's security posture.
• Partner with leadership to define and enforce security policies, access controls, and incident response procedures.

• Establish and maintain a company-wide software license tracking process, ensuring accurate visibility into license counts, utilization, renewals, and compliance.
• Identify opportunities to optimize license spend and eliminate underutilized or duplicate software.
• Partner with Finance and department leaders on software budgeting and vendor renewals.

• Develop, document, and maintain IT policies and procedures covering infrastructure, security, access management, and change control.
• Own IT General Controls (ITGC) testing, evidence collection, and audit support for Sarbanes-Oxley (SOX) compliance, partnering with Internal Audit, external auditors, and Finance.
• Ensure IT controls and documentation are audit-ready and support the company's transition to public-company operating standards.

• Serve as the operational leader for IT infrastructure and, as the team scales, assume oversight of the helpdesk/end-user support function.
• Manage relationships with infrastructure, network, and security vendors, including contract negotiation, service-level expectations, and performance management.
• Provide technical guidance, mentoring, and feedback to IT operations staff, promote knowledge sharing, and help build a collaborative, accountable team culture.
• As the IT Operations function grows, support hiring and onboarding, help define roles and team operating rhythms, and be prepared to assume direct people-management responsibility.
• Other duties as assigned by…