Senior Research Associate- Diagnostic Assay Development

About the Role:

10x Genomics is establishing a diagnostics effort, translating our leading single cell and spatial assay technologies into impactful clinical applications. We are seeking a highly skilled and motivated Senior Research Associate to join the Diagnostic Assay Development team. The SRA will be a key contributor, executing the technical development, optimization, and rigorous testing of novel Laboratory Developed Tests (LDTs) in a dynamic, high-growth environment.

This role, reporting to the Sr. Manager, Diagnostic Assay Development, requires extensive hands-on experience in advanced molecular biology techniques and a dedication to high-quality data generation in support of ambitious product development goals.

What you will be doing:

Assay Execution and Optimization

• Hands-on execution of complex single-cell and spatial genomics assays (e.g., sample processing, library preparation, sequencing).
• Systematically troubleshoot, optimize, and refine specific steps within the assay workflow to improve performance, robustness, and efficiency.
• Perform feasibility studies on new reagents, instrumentation, and process improvements for clinical readiness.
• Prepare and process samples in support of large-scale clinical research studies

Documentation and Analytical Studies

• Generate and maintain meticulous laboratory records, protocols (SOPs), and batch records following Good Documentation Practices (GDP).
• Execute formal experiments for analytical validation studies, including assessment of accuracy, precision, limit of detection, and reproducibility.
• Ensure all work is conducted under appropriate quality controls
• Present experimental data clearly and concisely in team meetings and written reports.

Cross-Functional Collaboration

• Support the transfer of robust assay workflows to the CLIA operations team.
• Collaborate closely with R&D Scientists, Automation Engineers, and Bioinformatics teams to meet project milestones.
• Work closely with the internal lab operations team to support the maintenance of a high-quality, organized laboratory environment, including inventory management and forecasting, equipment calibration, and ensuring compliance with safety standards.

Minimum Requirements:

• B.S. or M.S. in Molecular Biology, Genetics, Biochemistry, or a related scientific field.
• B.S. with 5+ years or M.S. with 3+ years of hands-on experience in molecular diagnostics or genomics assay development in an industry setting.
• Direct, demonstrable experience with advanced molecular technologies, particularly Next-Generation Sequencing (NGS) workflows
• Exceptional proficiency in molecular biology techniques, including nucleic acid extraction, PCR/qPCR, and NGS library preparation
• A proven track-record of using and optimizing and troubleshooting molecular biology protocols.
• Experience working with challenging clinical sample types (e.g., FFPE tissue, primary tumor cells, low-input samples).
• Experience working within a quality system or environment governed by CLIA, CAP, or ISO 13485 standards strongly preferred.
• Prior hands-on experience with 10x Genomics single-cell or spatial technologies (e.g., Chromium or Xenium platforms) is a strong advantage.
• Experience with automated liquid handling for high-throughput assay execution is a strong advantage; experience with microscopy techniques a plus

Preferred Skills & Experience:

• Ability to organize, analyze, and interpret complex data sets (e.g., assay metrics, quality control data) and effectively troubleshoot issues based on results.
• Commitment to rigorous execution, meticulous record-keeping, and high standards of scientific quality.
• Possess excellent communication skills, and can effectively collaborate with interdisciplinary teams, integrating their feedback into your experimental design.
• Thrive in fast-paced environments, and excel at managing multiple priorities, adapting to change, and consistently delivering results.

#LI-MH1 #LI-Onsite

Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one's skills, qualifications, and experience. At 10x, base pay is also just one component of the Company's total compensation package. This role is also eligible for 10x's equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program.

During the hiring process, your 10x recruiter can share more about the Company's total compensation package.

Pay Range

$97,700-$132,100 USD

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and…