Scientist, Research Scientist

Position Overview

We are looking for a highly motivated and skilled Principal Scientist to support the development of advanced molecular diagnostics technologies. The role requires expertise in preparative chromatography and analytical techniques throughout the product development lifecycle.

• Synthesize, purify, and characterize complex nucleotides, phosphoramidites, oligonucleotides, analogs, and related small molecule reagents.
• Drive process optimization to enable efficient scale‑up and successful product launches.
• Support and utilize analytical methods for characterizing reagents, reactions, and assay performance across R&D and Operations.
• Design and execute advanced troubleshooting experiments independently and collaboratively with cross‑functional teams.
• Develop assays that push system limits of understanding and error detection to ensure robust designs.
• Manage knowledge handoffs between prototype methods and transfer documentation from research to development and manufacturing.
• Act as a subject matter expert to provide technical depth across R&D departments and operations.

• Ph.D. in Chemistry, Biochemistry, Chemical Biology, Medical Chemistry, or related field with at least 2–3 years of industry experience; or a Master’s degree with 5+ years of industry experience.
• Demonstrated expertise in UPLC/HPLC, ion‑pair chromatography, ion‑exchange, advanced mass spectrometry, absorption spectroscopy, and fluorescence spectroscopy.
• In‑depth knowledge of synthetic methods for nucleotides, phosphoramidites, and oligonucleotides, including post‑synthetic modifications.
• Strong understanding of PCR methodologies and modified oligonucleotides (dye‑ and non‑natural modifications). Strong experience in purifying and characterizing oligonucleotides and small molecules.
• Proven experimental design skills, especially in developing and optimizing sophisticated analytical assays for oligonucleotides and PCR.

• Excellent technical writing and documentation skills, producing clear analytical reports.
• Proactive problem‑solving, growth mindset, and collaborative workplace culture engagement.
• Interpersonal skills: strong verbal communication, influencing without authority, and experience building partnerships with key stakeholders.

Salary range for Pleasanton, CA: $111,000 – $206,500, based on experience, qualifications, and geographic location. Possible discretionary annual bonus.

Position also qualifies for the company benefits.

Roche is an equal‑opportunity employer. We are committed to providing a workplace free from unlawful discrimination and ensuring equitable opportunities for all employees and applicants.