Senior Scientist

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The Position

For nearly 25 years, Roche has been at the forefront of innovating companion diagnostics (CDx) that hold the power to transform patients' lives by providing essential information that informs clinical decision-making and guides personalized treatment strategies.

With a steady pipeline of high medical value predictive tests fueled by collaborations with over 85 pharmaceutical partners, we deliver diagnostic certainty through the broadest menu of immunohistochemistry/in situ hybridization (IHC/ISH) companion diagnostics available today.

We are seeking a highly motivated and experienced IHC senior scientist with a strong histology/pathology background to join our innovative research and development team. This is a technical position within our antibody development group, focused on developing high quality rabbit monoclonal antibodies against novel biomarkers for tissue applications.

The Opportunity:

Antibody Discovery & Development:

• Lead the IHC functional screening for novel rabbit monoclonal antibodies against emerging and clinically relevant biomarkers.
• Apply deep knowledge of biomarker biology and histology/pathology to guide antibody selections.
• Analyze biomarker expression patterns across tissues, cell types, and tumor models to ensure appropriate targeting and clinical relevance.
• Interpret complex staining patterns and correlate with biological and pathological context.

IHC Assay Development & Optimization:

• Develop, optimize, and standardize IHC assays using FFPE samples.
• Evaluate antibody performance across normal and diseased tissues, including diverse tumor types and cell lines.
• Improve assay sensitivity, specificity, and reproducibility for diagnostic applications.

Research Sample Testing & Performance Improvement:

• Conduct IHC testing on research and preclinical samples to assess antibody performance.
• Identify opportunities to enhance antibody productivity, stability, and sensitivity through iterative testing and optimization.
• Troubleshoot technical challenges and implement solutions to improve assay robustness.

Validation & Documentation:

• Perform analytical validation including specificity, sensitivity, reproducibility, and robustness studies.
• Utilize orthogonal methods (e.g., Western blot, ELISA, RNA ISH, IF) to confirm antibody performance.

Leadership &

Collaboration:

• Provide scientific leadership and mentorship to junior scientists and research staff.
• Collaborate cross-functionally with R&D, pathology, operation, and regulatory teams.
• Contribute to scientific strategy, publications, patents, and external collaborations.

This is an onsite position based in Pleasanton, CA.
Relocation benefits are not being offered.

Who You Are:
(Required)

• You have a Bachelor of Science in Biology (or related field) plus 10 years relevant experience; or a master's degree in Biology (or related field) plus 6 years; or a PhD in Biology (or related field) and 4 years relevant experience.
• You have 3+ years of experience with immunohistochemistry (IHC) based methods.
• You have 3+ years of experience in a solid background in Pathology, Histology or Oncology
• You have the ability to translate biological insights into practical assay development strategies.
• You have strong analytical and critical thinking skills with attention to detail; you have the ability to manage multiple projects and drive results in a fast-paced environment; you have a collaborative mindset with demonstrated leadership capabilities.

Technical Expertise:

• Deep understanding of histology, capable of recognizing different tissues and cell types on FFPE samples.
• Understanding of biomarker expressions across tissues, cell types, and tumor cell lines.
• Proven experience working with novel or poorly characterized…