Associate Scientist, Cell Biology

About us

e184 is a biotechnology research company with the mission of advancing in vitro gametogenesis to solve one of biology’s most profound challenges: returning the fundamental right to procreate.

We work at the frontier of cutting-edge technology, integrating cellular reprogramming, machine learning-guided optimization, multi-omics analysis, and automated experimental workflows to enable gamete development for individuals facing reproductive challenges.

As an Associate Scientist at e184, you will be a key driver of our experimental operations, executing the high-throughput screening and cell engineering workflows central to our mission. Reporting to the CSO, you will take ownership of establishing robust cellular assay platforms and generating the engineered cell lines that fuel our stem cell differentiation research. This is a high-impact, hands-on role designed for a technically elite scientist who excels in a fast-paced, well-funded startup environment where excellence in execution directly enables breakthrough discovery.

• Master cell culture: Maintain and characterize pluripotent stem lines and primary cells while optimizing conditions for peak experimental performance.
• Engineer next-gen lines: Own end-to-end genetic engineering workflows, including construct design, clone screening, QC assays, and the establishment of stable reporter systems.
• Drive discovery: Execute large-scale genetic screening experiments (pooled/arrayed) that directly inform our R&D roadmap.
• Pioneer workflows: Establish and scale robust cellular assay platforms and automation-friendly workflows from the ground up.

• BS (4+ years) or MS (3+ years) in Molecular/Cell Biology or related field
• Expert-level mammalian cell culture and sterile technique (human iPSCs/ESCs preferred)
• Proficient in molecular biology techniques (PCR, gels, plasmid preparation)
• Basic flow cytometry experience (sample preparation and data collection)
• You are reliable, adaptable, and ready to tackle occasional weekend maintenance to keep the science moving.

• Industry R&D experience in biotech or pharmaceutical settings
• Hands-on experience with CRISPR/Cas9 genome editing, including reporter cell line generation and validation
• Involvement in genetic screening projects (pooled or arrayed)
• Transposon-based engineering (Piggy Bac/Sleeping Beauty)
• Next-gen sequencing (RNA-seq/Single-cell) sample prep
• Immunofluorescence microscopy and imaging
• Experience with high-throughput automation or liquid handling.

• Unrivaled impact
  :
  Your work directly enables technology that transforms human fertility and reproductive medicine.
• Full-spectrum growth
  :
  Gain exposure to the entire lifecycle of discovery. From screening to mechanistic validation.
• Best of both worlds
  :
  Experience the creative chaos of an early-stage startup with the stability of a well-capitalized company.
• Elite collaboratio
  n:
  Work alongside a world-class team who are as driven as you are.

• Competitive salary + equity participation is considered
• State-of-the-art facility in Portland metro area
• Comprehensive Medical, Dental, Vision, and 401(k) with company match
• 20 days PTO + 11 paid holidays

Disclaimer

The above job description is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary.

The job description is subject to change at any time at the discretion of e184.