Scientist, Cell Engineering & Screening

About us

e184 is a biotechnology research company with the mission of advancing in vitro gametogenesis to solve one of biology’s most profound challenges: returning the fundamental right to procreate.

We work at the frontier of cutting-edge technology, integrating cellular reprogramming, machine learning-guided optimization, multi-omics analysis, and automated experimental workflows to enable gamete development for individuals facing reproductive challenges.

As a Scientist at e184, you will own high-throughput screening campaigns from end to end - designing experiments, executing them at the bench, analyzing results, and iterating to drive discovery. Reporting to the CSO, this is a high-impact, hands-on role for an independent scientist who excels at translating experimental data into actionable insights in a well-funded startup environment where your science directly enables breakthrough discovery.

• Engineer reporter systems: Design, generate, and validate CRISPR-based reporter lines and develop quantitative cellular assays hands-on to enable robust phenotypic screening readouts.
• Own screening end-to-end: Design TF screening experiments (pooled and arrayed), construct screening libraries, execute experiments at the bench, and manage sample processing through hit validation.
• Drive the discovery cycle: Analyze screening data to identify hits, validate candidates through arrayed experiments, characterize mechanisms of action, and design next-iteration screens.
• Collaborate across disciplines: Partner with bioinformaticians on experimental-computational workflow integration and with biology experts to ensure screening readouts capture biologically meaningful phenotypes.

• PhD in Cell Biology, Molecular Biology, Genetics, Biochemistry, or related field
• Hands-on high-throughput screening experience (pooled and/or arrayed) with mammalian cells, including iPSCs
• CRISPR/Cas9 genome editing and reporter development expertise
• Strong molecular biology foundation (cloning, plasmid design, library construction) and quantitative assay development
• Flow cytometry or high-content imaging for cellular analysis
• You are reliable, adaptable, and ready to tackle occasional weekend maintenance to keep the science moving

• Industry R&D experience in biotech or pharmaceutical settings
• Track record of end-to-end screening project ownership - from design through execution and validation
• Experience with high-throughput automation or liquid handling
• Hands-on sequencing experience (scRNA-seq, ATAC-seq) including library prep, plus proficiency with bioinformatics tools
• Immunofluorescence microscopy and imaging

• Unrivaled impact
  :
  Your work directly enables technology that transforms human fertility and reproductive medicine.
• Full-spectrum growth
  :
  Gain exposure to the entire lifecycle of discovery. From screening to mechanistic validation.
• Best of both worlds
  :
  Experience the creative chaos of an early-stage startup with the stability of a well-capitalized company.
• Elite collaboration
  :
  Work alongside a world-class team who are as driven as you are.

• Competitive salary + equity participation is considered
• State-of-the-art facility in Portland metro area
• Comprehensive Medical, Dental, Vision, and 401(k) with company match
• 20 days PTO + 11 paid holidays

The above job description is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary.

The job description is subject to change at any time at the discretion of e184.