Postdoctoral Scholar

Cancer Early Detection Advanced Research (CEDAR) center is a collaborative institution within the OHSU Knight Cancer Institute. The Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. At CEDAR our mission is to detect and stop lethal cancers at the earliest stage because early detection saves lives. This is an ambitious goal, one that requires novelty, creativity, and innovation.

We are composed of biologists, chemists, biomedical engineers, computational biologists, and clinicians conducting groundbreaking translational cancer research to help people maintain a high quality of life and reduce cancer mortality, to create a global early detection community, and to have a positive impact on the Oregon economy.

CEDAR is committed to increasing the diversity of the campus community. We at CEDAR are dedicated to promoting inclusion and multiculturalism to build a successful organization by having outstanding researchers of diverse backgrounds work together on multiple projects. We encourage high-risk, high-reward research projects because defeating cancer requires unproven, out-of-the-box thinking. Our research is milestone driven to ensure that each project is fulfilling its stated goals.

Every Knight Cancer employee is expected to embody our guiding principles:

• We act BOLDLY—Breakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently
• We SUPPORT each other—Respect leads to trust, which leads to excellence
• We work as a CONNECTED team—We must leverage our collective brain power to conquer cancer because no one individual can do it alone

CEDAR funds its own research projects, expediting the process of discovery. Our research is milestone-driven to ensure that each project is fulfilling its stated goals. CEDAR offers a unique opportunity for outstanding, driven, and creative postdoctoral fellows to perform cutting edge and high-risk research, ranging from understanding basic cancer biology to developing novel technologies to aid detection. Our focus on early detection requires novel approaches to reliably identify small/rare signals in diverse data types, with an emphasis on minimally invasive sampling techniques.

We are currently hiring for a highly motivated fellow with expertise in Cancer Biology to work in the following areas. Candidate would primarily work with Dr. Ece Eksi, Assistant Professor in the Division of Oncological Sciences with affiliations in the Biomedical Engineering and Cell, Development and Cancer Biology departments.

• Spatial imaging of the prostate tumor microenvironment – Performing multiplex imaging on patient samples acquired from prostate and pancreatic cancer patients to analyze intercellular interactions across cells in the microenvironment. The successful candidate will have the opportunity to learn existing experimental protocols and computational pipelines to generate and analyze single-cell, multiplex imaging data sets to aid clinical decision-making processes in cancer diagnostics.

• Single-cell transcriptomics and epigenomics – Generating single-cell libraries that measure the transcriptome and the epigenome of patient samples, specifically single-cell RNA-seq and ATAC-seq. The successful candidate will use both existing experimental protocols and computational pipelines to generate and analyze datasets for the characterization of prostate and pancreatic tumors.

Select references:

• https://(23)00077-9/fulltext
• https://(Use the "Apply for this Job" box below)..553854v1

• M.D., M.D./Ph.D., or Ph.D.
• Minimum of 3 years as a graduate student
• Specialty:
  Molecular Biology, cell biology, genome sciences, epigenomics, or related field
• Excellent communication, analytical and organizational skills
• Ability to work independently and as part of a team while being collaborative in resolving problems
• Passion for science and inquiry
• Ability to synthesize one’s own results and others to formulate hypotheses
• Ability to prioritize multiple tasks at one time
• Must possess energy and drive to coordinate multiple projects simultaneously
• Ability to use tact and diplomacy to maintain…