Postdoctoral Scholar

The primary mission of the Division of Oncological Sciences at OHSU's Knight Cancer Institute is to better understand cancer through basic, translational and population-based research that improves cancer prevention, detection and treatments for all. Our community of faculty, trainees and staff brings together scientists from a broad range of disciplines and works collaboratively to advance innovation and translate discoveries from the lab into meaningful impacts for cancer patients and our community.

Applications are invited for a Postdoctoral Research position in the laboratory of at the OHSU Knight Cancer Institute. The Agarwal laboratory focuses on identifying novel intrinsic and extrinsic signaling pathways that are requisite for leukemia progression, clonal evolution, and drug resistance. The work will focus on discovering the mechanisms of leukemia initiation and drug resistance using multi-omics approaches in murine models and primary human samples for funded projects.

Dr. Agarwal and her team have been focusing for over the past 20 years on identifying novel signaling pathways that are requisite for leukemia initiation, clonal evolution, and drug resistance. The new team member will help lead the project focused on understanding the mechanisms of leukemia initiation and drug resistance. The project will use a variety of advanced molecular biology techniques, CRISPR methods, and flow cytometry analysis, along with single-cell transcriptomic, epigenetic, and genomic profiling in premalignant and malignant models.

The candidate is required to have experience in hematology, including functional assays and molecular biology methods, and to work with primary samples using murine models and human samples. A candidate should also be able to perform complex data analysis and downstream analyses using computational approaches. Applicants will need to possess strong technical and organizational skills as well as the ability to manage an independent project.

A PhD with 0-2 years of research experience in the relevant field is preferred
. Laboratory experience in hematology or a related field is preferred.

Experience with sequencing library preparation, epigenetics, flow cytometry, or murine disease models would be especially beneficial. Achieving this position requires that the researcher have demonstrated a satisfactory track record of scholarly activity, including high-quality peer-reviewed publications. We are looking for an enthusiastic individual who is capable and willing to make maximum use of excellent facilities and a productive environment.

The OHSU Knight Cancer Institute is a pioneer in personalized cancer treatment and research, led by Dr. Brian Druker, whose development of Gleevec transformed Chronic Myeloid Leukemia from a fatal disease to a manageable one and proved that targeted therapies can work. The institute focuses on precision oncology, the early detection, prevention, and treatment of cancer, and creating a welcoming and supportive environment for its caregivers, researchers, and support personnel.

Knight affiliates subscribe to three guiding principles: we are bold, we are supportive, and we work as a connected team in our fight to end cancer as we know it. We’d love for you to join us!

Relevant publications for the position are below: