Senior Manager, Principal Software Engineer, Clinical Pharmacology and Pharmacometrics

Working with Us:
Challenging. Meaningful. Life‑changing. Those aren’t words normally associated with a job, but at Bristol Myers Squibb the work transforms the lives of patients and the careers of our people. You’ll grow through unique opportunities and high‑achieving teams that go beyond the ordinary expectations of a career.

The Principal Software Engineer will lead the design, development, and deployment of innovative software and data platforms supporting Clinical Pharmacology & Pharmacometrics within BMS R&D. This role partners closely with computational scientists and IT teams to enable advanced analytics, modeling, simulation, and workflow optimization, leveraging cloud, HPC, AI/ML, and modern data technologies to accelerate drug development and translational science.

• Support deployment and operation of AI/ML models, simulation tools, and dashboards for scientific users.
• Lead the integration of HPC, cloud, and Kubernetes‑based compute environments; optimize parallelization and resource utilization.
• Collaborate with domain scientists, IT, and stakeholders to translate scientific workflows into robust technical solutions.
• Drive continuous improvement through automation, system upgrades, and stakeholder feedback.
• Manage platform security, validation, and compliance in coordination with IT and cybersecurity teams.
• Architect, develop, and maintain scalable software systems and data platforms for clinical pharmacology and pharmacometrics use cases.
• Mentor engineers and contribute to best practices (CI/CD, Agile).
• Troubleshoot, monitor, and optimize performance of deployed systems.

• BS/MS/PhD in Computer Science, Software Engineering, or related field; higher degrees preferred.
• 7+ years hands‑on experience in software engineering, ideally in life sciences or healthcare domains.
• Proven track record architecting and delivering production‑grade software and data platforms (preferably supporting scientific research, modeling or analytics).
• Experience in cross‑functional collaboration within matrixed, stakeholder‑driven environments.

• Python (primary) and R programming with API integration in AWS or Google Cloud; familiarity with Markdown languages such as Quarto/Typst.
• Experience building GenAI applications and agentic workflows, including fine‑tuning and deploying large language models, prompt engineering, and automating complex document generation.
• Knowledge of AWS, Azure, GCP, HPC, Kubernetes, and parallel/distributed computing.
• Familiarity with software validation, compliance, and best practices in regulated environments.
• Deep understanding of all aspects of the software development lifecycle and SDLC methodologies (Agile, Scrum, Waterfall, etc.).
• Experience with MATLAB, WebAPP, and related scientific tools.
• Excellent problem‑solving, communication, and stakeholder engagement skills.

• Knowledge of vector databases and graph RAG.
• Experience with Posit Workbench/RStudio Server, NAS integration, or similar collaborative scientific platforms.
• Knowledge of QSP, PBPK, PK/PD modeling or pharmaceutical R&D workflows.
• Experience implementing robust access controls, NFS, ACLs, and enterprise authentication.
• Agile and Dev Ops methodologies, CI/CD, and automation scripting (e.g., Bash, Ansible, Cloud Formation, Terraform).

Cambridge, MA – $165,120 to $200,088
Princeton, NJ – $150,110 to $181,898
Starting compensation is based on experience, location, and role responsibilities. Additional incentive cash and stock opportunities may be available.

• Health coverage: medical, pharmacy, dental, and vision.
• Well‑being support programs, including the BMS Well‑Being Account, BMS Living Life Better, and Employee Assistance Programs.
• Financial stability: 401(k) plan, disability coverage, life insurance, supplemental health insurance, and more.
• Paid time off: flexible time off (unlimited for exempt employees with manager approval), national holidays, and optional holidays, with additional unpaid time for medical, personal, parental, caregiver, bereavement, and military needs. Global shutdown from Christmas to New Year’s.

BMS classifies roles into site‑essential, site‑by‑design, field‑based, and remote‑by‑design. Occupancy type is determined by the nature of the role. Site‑essential positions require 100% onsite shifts. Site‑by‑design roles may have a hybrid model with at least 50% onsite.

BMS is an equal opportunity employer and actively encourages qualified persons of all backgrounds to apply. For a full EEO statement, visit

If you are intrigued by this role—even if your resume doesn’t match every requirement—please apply. Visit  for application details.

For recruitment questions or accommodation requests, contact

R1597734 – Senior Manager, Principal Software Engineer, Clinical Pharmacology and Pharmacometrics