Director, Clinical Genomics & Molecular Assay Development

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Position Summary

Bristol Myers Squibb (BMS) is a global biopharmaceutical company engaged primarily in the discovery, development and commercialization of novel therapies for the treatment of human diseases. The Director, Clinical Genomics & Molecular Assay Development (MAD) will provide strategic and scientific leadership for clinical genomics, transcriptomics, and molecular biomarker assay activities supporting Translational Medicine and clinical development programs across BMS's pipeline.

As a functional leader within Clinical Genomics & MAD, this role partners closely with Biomarker Leads, Data Analysis, Biostatistics, Sample Management, Clinical Operations, Translational Medicine, Quality, and external laboratories/CROs to define assay strategy, enable fit-for-purpose validation, and deliver high-quality genomic data to support critical program decisions. The position reports to the Senior Director, Head of Clinical Genomics & MAD, and manages lab scientist direct reports, interfaces with matrix teams and supervises outsourced work with external partners globally.

Key Responsibilities:

* Provide strategic leadership and accountability for clinical genomics, transcriptomics, and molecular assay strategies across translational medicine and clinical development programs.

* Lead genomics biomarker strategy with program biomarker leads, data analysis, and clinical operations teams, aligning assay plans with protocol needs, program biology, and mechanism of action.

* Oversee assay and platform selection for broad genomic profiling, gene expression profiling, pharmacodynamic, target engagement, predictive, prognostic, genotyping, ctDNA, and variant analysis applications.

* Direct assay design, development, optimization, qualification, validation, and lifecycle management for NGS-, PCR-, qPCR-, and related molecular platforms, ensuring methods are fit-for-purpose and operationally robust.

* Manage a team of direct reports, supervising clinical genomic projects ensuring quality outputs and on-time delivery of data to study times meeting timelines.

* Maintain a strong laboratory presence by dedicating substantial time to hands-on experimental work and direct support of core lab operations.

* Drive innovation through the evaluation, onboarding, and implementation of emerging genomics technologies and assay methodologies to improve performance, scalability, and efficiency.

* Provide strategic oversight and hands-on leadership for internal and outsourced assay execution, including:

* Vendor selection and scientific oversight of assay development and clinical sample testing

* Authoring and review of experimental plans, validation reports, work instructions, technology transfer documents, study summaries, and SOPs

* Troubleshooting assay/platform performance and establishing appropriate controls and QC methodologies

* Partner cross-functionally with data analysis, biostatistics, sample management, and trial operations teams to define data structure, QC review, interpretation, and delivery of clinical genomics results.

* Serve as the genomics subject matter expert for functional stakeholders, portfolio teams, and study teams, providing strategic input on technology, data quality, outsourcing, and execution risk.

* Lead, mentor, and develop scientific…