Head of Medical Affairs

Head Of Medical Affairs

Princeton New Jersey

Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world. It is Kardigan's mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve. Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan's co-founders have reunited after leading Myo Kardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients. At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals.

Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic—leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds.

We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries. These values are the foundation of our work, empowering us to make a real difference, every day.

Job Overview

Kardigan is seeking a Head of Medical Affairs to lead, unify, and scale our Medical Affairs organization as we advance a portfolio of investigational cardiovascular therapies through late-stage development toward potential registration and launch readiness. Reporting to the Chief Executive Officer, this leader will partner closely with the CEO and Executive Leadership Team to create and execute Kardigan's Medical Affairs strategy across prioritized cardiovascular indications.

Medical Affairs at Kardigan is already taking shape, with strong talent in place or being recruited across disease-area medical leadership, program-dedicated Medical Affairs leads, scientific communications, publications and medical information, and congress strategy. The Head of Medical Affairs will bring this team together under a unified strategy and operating model while designing and building the capabilities still ahead — including field medical (MSLs), integrated evidence generation (HEOR and real-world evidence), medical review, and medical operations and governance — and will own the function's budget, headcount plan, and organizational design as Kardigan grows.

Early priorities include aligning the existing team and Executive Leadership Team around a cohesive Medical Affairs strategy and organizational blueprint, making key hires to enhance capabilities, expanding KOL and scientific advisory engagement for the lead indication, scaling publication and congress planning ahead of late-stage data readouts, establishing launch-readiness work streams with Commercial, Regulatory, and Safety, and strengthening the compliance and governance framework for scientific exchange.

The Head of Medical Affairs will serve as a strategic partner across the business, particularly with Clinical Development and Commercial, and will establish and maintain critical relationships across the medical and scientific communities. Kardigan is deeply committed to the patient journey and to developing medicines with the…