Director, Commercial Excellence

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people.

Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.

Summit’s team is inspired to touch and help change lives through Summit’s clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including:

Non-small Cell Lung Cancer (NSCLC)

HARMONi:
Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.

HARMONi-3:
Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.

HARMONi-7:
Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

HARMONi-GI3:
Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.

Overview of Role:

The Director, Commercial Excellence is a headquarters-based role within Summit Therapeutics Commercial Operations. This role owns the governance and execution layer of the Commercial Excellence function — incentive compensation administration, territory design and change management, CRM configuration and administration, targeting and segmentationmethodology, field reporting standards, and the national KPI framework. The Director reports to the Senior Director, Commercial Excellence and is the day-to-day operational counterpart to Marketing, Market Access, and Medical Affairs Operations,and Market Researchensuring every functionoperatesfrom a consistent, compliant, and well-governed infrastructure.

This is a role for someone who thrives on building from scratch, can manage multiple work streams simultaneously, and understands that operational excellence in oncology commercial launch is the foundation that makes field execution possible.

Role and Responsibilities:

• Own incentive compensation design and administration — plan design, quota setting, goal crediting, dispute resolution, and payment accuracy across the full field organization
• Own territory design and alignment — build andmaintainthe territory structure, manage alignment changes through a defined change governance process, andensure roster accuracy at all times
• Own CRM configuration and administration — partner with IT and the Director of Commercial Data and Technology to configure,maintain, and continuously improve the CRM; own business requirements, user access, and data quality
• Own targeting and segmentationmethodology— define andmaintainthe HCP and HCO targeting approach, manage decile assignments, and ensure targeting outputs are operationalized in the CRM and field tools
• Define and govern national KPI standards —establishfield reporting…