Principal Scientist, Cardiovascular Translational Biomarker

Principal Scientist, Cardiovascular Translational Biomarker Position Summary

We are seeking a translational scientist with a background in cardiovascular biology to identify and discover novel and existing biomarkers to support the progression of late‑discovery programs to early phase clinical trials and beyond. This role involves close collaboration with the development organization and may serve as a liaison of discovery to development. The successful candidate will collaborate closely with early discovery team members to drive program progression, assist in pharmacology studies, guide selection and analysis of endpoints, and support early translational development plans, including patient segmentation hypotheses.

The portfolio may include in vivo, functional‑structural analyses and ex vivo or in vitro biochemical or molecular assays, and development of novel assays. The position may work with human samples or relevant systems to test translational hypotheses. This is primarily a lab‑based, on‑site position with lab time dependent on programmatic needs.

• Perform studies to define pharmacodynamic biomarkers of response and disease progression, and articulate how these biomarkers may translate to the clinic.
• Apply comprehensive knowledge of experimental design and advanced laboratory techniques (cell culture, immunoassays such as ELISA/MSD, IHC, protein signaling, qPCR platforms) and interpret results.
• Make experimental in‑life modifications as needed, employing technical knowledge and theory.
• Lead studies to completion, including hands‑on analysis of samples internally or managing CROs externally.
• Critically evaluate programs and present findings and recommendations to discovery teams and leadership.
• Document, review, modify experimental approach when necessary, and present data in a timely manner.
• Collaborate with cross‑functional teams to provide timely and actionable results.
• Provide hands‑on training and guidance to develop team members.
• Contribute to and author reports, abstracts, and publications.

• Bachelor’s Degree with 8+ years of academic and/or industry experience.
• or Master’s Degree with 6+ years of academic and/or industry experience.
• or Ph.D. or equivalent advanced degree in the Life Sciences with 4+ years of academic and/or industry experience.

• Ph.D. in Physiology, Pharmacology, Biology, Biochemistry, or related field with 2+ years of relevant industry experience and 5+ years after completion of terminal degree, including post‑doctoral training.
• PharmD/DVM/MD with a strong track record in basic sciences or drug discovery considered.
• M.S. in a related field with 5+ years of industry experience after graduation.
• Strong understanding of cardiovascular physiology and modern cardiovascular methodologies employed pre‑clinically and clinically.
• Understanding of imaging biomarkers such as ultrasound‑echocardiography, MRI, and PET.
• Experience designing animal studies with focus on species‑specific use and application of 3
  
  Rs principles.
• Hands‑on experience handling rodents and culturing iPSC‑CM, primary cardiac cells, or engineered heart tissues.
• Excellent laboratory skills with emphasis on accuracy and reproducibility.
• Ability to manage external collaborators and set clear timelines.
• Self‑motivated, detail‑oriented, collaborative, and effective in multidisciplinary teams.

Princeton, NJ – US $135,800 – $164,563. The starting compensation range reflects skills, location, schedule, and experience. Additional incentive cash and stock opportunities may be available.

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws. BMS is committed to hiring qualified applicants with disabilities and providing reasonable accommodations.