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Principal Scientist, Cell Line Genome Engineering
Job in
Princeton, Mercer County, New Jersey, 08543, USA
Listed on 2026-08-30
Listing for:
Scorpion Therapeutics
Full Time
position Listed on 2026-08-30
Job specializations:
-
Research/Development
Research Scientist
Job Description & How to Apply Below
Responsibilities:
- Design, engineer, and validate physiologically and/or disease-relevant cellular systems to enable initiation and progression of drug discovery programs.
- Develop advanced engineered cellular models to support drug discovery within Lead Discovery and Optimization.
- Guide project teams in selecting appropriate cellular models at project outset to ensure biological alignment and maximize translational impact.
- Collaborate with internal teams and external academic/industry partners; integrate insights into innovative, research-driven solutions.
- Master's degree in molecular biology, cell biology, bioengineering (or related) and 6+ years academic/industry experience OR PhD and 4+ years academic/industry experience.
- Deep genome biology knowledge (gene regulation and impact on cellular function) applied to engineered cellular systems.
- Hands‑on CRISPR genome engineering (e.g., Cas9/Cas
12a/dCas9; base/prime editing) and gene delivery methods (lentiviral, AAV, electroporation, transposon) to build/scale/optimize cellular models. - Expertise engineering diverse cellular systems (established cell lines, primary cells, physiologically relevant models) and model selection for discovery questions.
- High‑content imaging and cell painting experience.
- Genomic sequence analysis/bioinformatics including short/long‑read sequencing for experimental design, clonal characterization, and validation.
- Experience integrating AI‑guided/AI‑enabled cell line engineering (computational models to design/interpret perturbations and phenotypes).
- Strong analytical/data interpretation skills; ability to influence scientific/strategic decisions.
- Lead/influence cross‑functional teams in a matrixed environment; excellent communication.
- Health coverage
- wellbeing support programs
- 401(k)
- disability/life/insurance
- legal support
- paid time off (including flexible time off/annual vacation per eligibility)
- potential additional time off (e.g., sick time, volunteer days, leaves, Global Shutdown)
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