Principal Scientist, Cardiovascular, Translational Development

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits.

This is work that transforms the lives of patients, and the careers of those who do it.

Translational Development is part of the Global Research organization in BMS and leads late stage clinical, pharmacological and translational research and development activities for the pipeline and supports late stage portfolio for regulatory, translational development and life cycle management. Translational Development drives strategy across core therapeutic areas at BMS including hematology, oncology, immunology, cardiovascular and neuroscience. This group integrates laboratory science, clinical trial/biomarkers and asset development as well as disease research to maximize the potential of BMS current and future therapeutics.

Incumbents with deep training and education in cardiovascular, or related disease areas, including but not limited to neurocardiac research.

• Designs and implements program-specific development biomarker/translational plans
• Responsible for aiding in creation of clinical protocols, SAPs, SOWs, lab manual, and interfacing with CRO for execution of services, in conjunction with Biospecimen Operations and Procurement.
• Determines appropriate assays and vendors for clinical biomarkers, and manages outsourcing of biomarker assay development and validation partnering with Translational Sciences colleagues when applicable
• Manages clinical biomarker data delivery and analysis and associated timelines by working with relevant internal functions and CROs
• Prepares and delivers internal and external translational/biomarker presentations
• Maintains timelines for biomarker data related publication through interaction with Medical Communications and Publication team as needed
• Keeps up-to-date on relevant scientific/technical literature in order to applying external knowledge to internal research programs as appropriate and acts as a subject-matter expert within the team to critically evaluate the literature regarding the asset and disease biology
• Works with TM laboratory scientists and academic TLs to address nonclinical translational questions as needed
• Participates/leads post-hoc biomarker analysis and publication efforts
• Supports regulatory submissions and regulatory interactions as needed
• Participate in Diagnosis (PDx) biomarker assay development through collaboration with precision medicine group

• Expertise/knowledge in translational biomarkers in cardiovascular, or related disease areas.
• Experience in drug development and activities required for and related to clinical trial initiation, maintenance and completion
• Strong verbal and written communication skills
• Experience in interacting with CROs and TLs to manage projects and timelines
• Proven scientific/leadership expertise (working in teams, mentoring people, managing projects)
• Accountable for timelines and deliverables
• Prioritizes risks and implements contingency plans
• Experience in mining datasets, in collaboration with bioinformaticians to understand MoA, disease pathophysiology or establish patient segmentation hypotheses
• Communicates regularly; prepares and delivers presentations within the department, to governance and senior leadership bodies, and externally as requested
• Recognizes cross-functional issues and…