Drug Safety Physician

Syst Immune is a leading and well‑funded clinical‑stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi‑specific, multi‑specific antibodies, and antibody‑drug conjugates (ADCs). Syst Immune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications, and a robust preclinical pipeline of potential cancer therapeutics in the discover and IND‑enabling stages.

This individual will lead medical assessment and interpretation of safety data from multiple sources, including clinical trials and literature reports. The role requires close collaboration with cross‑functional teams to support all clinical development programs, regulatory filing, and global safety activities. The individual will also oversee PV service vendors and partners, maintaining medical knowledge and current knowledge of drug safety and pharmacovigilance regulations, practices, safety surveillance and risk‑management practices.

This role requires a full‑time onsite presence at our Princeton, NJ location.

• Provide medical safety input and participate in safety surveillance activities (e.g., identification of safety signals and ensure timely assessment and communication of confirmed safety signals).
• Provide input in the generation of aggregate safety reports (e.g., DSURs, PADER, PBRER).
• Serve as a leading medical safety resource for the development and review of clinical trial protocols, informed consent forms (ICFs), investigator brochures (IBs) and Reference Safety Information (RSI).
• Collaborate with Medical Monitors and Clinical Research Scientists and vendor clinical staff as needed for ongoing clinical trials.
• Provide medical safety input in the development and/or updates of Risk Management Plans and the maintenance of these documents.
• Provide support and input to the development of Standard Operating Procedures, Working Instructions, and other guidance documents.
• Serve as a subject matter expert for vendors that provide drug safety and pharmacovigilance services.
• Work closely with other Product Safety Leads to respond to and resolve safety questions from health authorities and regulatory agency audits and inspections.

• 5+ years’ experience in Drug Safety/Pharmacovigilance in a pharmaceutical or biotech company, CRO or regulatory agency.
• Medical Degree (MD) from a recognized medical school with medical practice experience;
  Oncology / Hematology experience strongly preferred.
• Strong working knowledge of US and EU drug safety and pharmacovigilance regulations, CIOMS and ICH guidelines.
• Proven experience in medical safety assessments, safety surveillance and risk management activities.
• Proficiency with medical review of ICSR’s, including expectedness assessments, causality assessments, narrative review and generation of Analysis of Similar Event and company comment statements, including benefit‑risk assessment.
• Experience with preparation of aggregate reports (e.g., DSUR, PSUR/PBRER, PADER).
• Experience in preparation of responses to regulatory authorities; experience with regulatory filing and related activities preferred.

The expected base salary range for this position is $150,000 - $250,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills.

Syst Immune offers a comprehensive benefits package: 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) plan with a 50% company match up to 3% and a vesting schedule of 5 years, 15 PTO days per year, sick leave, 11 paid holidays.

Syst Immune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.