Director, Translational Sciences

Description

About Century Therapeutics:
Century Therapeutics (NASDAQ: IPSC) is a biotechnology company advancing a pipeline of induced pluripotent stem cell (iPSC)-derived cell therapies with the potential to meaningfully address autoimmune diseases, including type 1 diabetes, and cancer. The company's therapies are derived from its iPSC cell foundry and leverage its novel immune evasion engineering technology, Allo-Evasion™. Century believes its approach to developing off-the-shelf cell therapies will expand patient access and provide advantages over existing cell therapies which will ultimately advance the course of care.

Role:

Century Therapeutics is seeking a Director of Translational Sciences to serve as a senior scientific and organizational leader driving translational strategy across our early-phase clinical programs, with a primary focus on Type 1 Diabetes (T1D) and CAR-T cell therapies. This is a high-impact leadership role with broad accountability for translational science, biomarker strategy, assay development, CRO oversight, and team growth. Reporting to the Head of Immunology & Translational Sciences, the Director will set and drive the strategic agenda for translational sciences, partner across Early Clinical Development, Computational Biology, Regulatory Affairs, and external CRO networks to ensure translational readiness and scientific rigor across first-in-human and early-phase trials.

The Director will operate with significant independence, lead cross-functional decision-making, and serve as the internal and external face of Century's translational science capabilities. The ideal candidate brings deep scientific expertise, a track record of leading biomarker and translational programs through IND and early-phase clinical milestones, and the leadership presence to build a high-performing team, influence senior stakeholders, and represent Century in industry forums and with regulatory agencies.

The expected salary range for this role is approximately $195,000 - $218,000 depending on experience. Additional benefits offered includes but are not limited to an annual performance-based bonus (prorated by start date), medical, dental, and vision insurance, matching 401K plan, and 20+ days per-year of PTO (prorated by start date). Additionally, employees not requiring sponsorship are preferred.

Requirements

• Define and drive the translational science strategy across Century's early clinical pipeline, ensuring alignment with corporate objectives and clinical development priorities.
• Serve as the primary scientific owner of translational strategy across T1D and CAR-T programs, integrating biomarker objectives into clinical protocols, sample collection plans, and trial timelines
• Contribute to functional area strategy and company-level decision-making as part of Century's management team.
• Represent translational sciences internally to senior leadership, governance committees, and program teams, and externally at scientific conferences, with regulatory agencies, and in collaboration with academic and industry partners.

• Lead development and execution of translational and biomarker strategies to support early-phase clinical trials, including first-in-human studies.
• Define clinical biomarker objectives, context of use, and analysis plans aligned with program mechanisms of action and regulatory expectations.
• Enable clinical decision-making through expert interpretation of patient-derived translational datasets and integration of insights into program strategy.
• Partner with Early Development, Clinical Operations, Regulatory, and Medical to ensure translational readiness at each stage of clinical development.

• Oversee and drive development, qualification, and validation of translational assays for treated patient samples, including:
• Immune phenotyping (flow cytometry)
• Cytokine and soluble biomarker assays
• Functional immune and cell therapy–related assays
• ADA-related assays
• Molecular biomarkers relevant to T1D and CAR-T therapies
• Ensure all assays are fit-for-purpose, scientifically…