Principal Scientist, Downstream Process Development

Overview

Job Description for a Principal Scientist in BPR&D within our Company's Research Laboratories focused on rapidly delivering biotherapeutics to patients by developing innovative, robust manufacturing processes and technologies.

We work closely with Discovery, Pre‑clinical, Early Development, Analytical, Formulation, and Commercial Manufacturing. In addition to pipeline biologics process development, we innovate in continuous manufacturing, green and sustainable processes, and proprietary technology platforms. We actively publish and engage the scientific community.

• Shape and realize innovation across the Biologics pipeline, strategy, and science.
• Advance the pipeline by collaborating with cross‑functional teams from Research & Manufacturing in a fast‑paced, multidisciplinary environment.
• Participate in or lead development of robust and scalable purification processes for biologics at different stages of clinical development and process characterization and regulatory filings for commercialization.
• Improve downstream process efficiency and cost effectiveness through research and innovation, and assess technologies and industry best practices.
• Collaborate with academia, industry, and vendors to drive development and early adoption of novel process technologies.
• Contribute to strategic initiatives; partner with senior leaders to set overall project strategy and guide teams toward execution.
• Conceptualize, plan, and execute projects with effective organization, prioritization, and problem‑solving skills.
• Stay abreast of the scientific and regulatory landscape; actively present at premier conferences, publish in peer‑reviewed journals, and file patents.
• Represent BPR&D as a downstream bioprocess expert in internal, cross‑functional project teams and external conferences/consortia.
• Mentor and share expertise; guide career development and build strong, collaborative teams.
• Champion compliance and safety; promote a culture of inclusion.

• Ph.D. with 6+ years experience.
• M.S. with 8+ years experience.
• B.S. with 10+ years experience.
• Background in Chemical/Biochemical engineering or a related field.

• Strong fundamental knowledge and subject matter expertise in downstream processing of biologics, recent advances, and challenges.
• Expertise in independently designing, executing, analyzing, and documenting all stages of purification process development.
• Track record of accomplishments in downstream bioprocessing with peer‑reviewed publications and presentations.
• Knowledge of biologics CMC development.
• Adaptability and agility to prioritize and deliver complex objectives on tight timelines in a rapidly changing environment.
• Experience and aptitude to lead, work, and collaborate in internal and external cross‑functional, matrixed teams.
• Action‑oriented mindset for creativity; initiative, innovation, iteration, and problem solving.
• Commitment to coach and mentor staff to maximize talent development and utilization.
• Excellent interpersonal and communication skills.

• Leadership of CMC development teams.
• Continuous biomanufacturing integrated with process‑analytical technologies.
• High‑throughput experimentation, automation, and process control.
• Knowledge of protein expression, analytics, conjugation chemistry, and formulation.
• Biophysical, mechanistic, and facility modeling; statistical analysis, data‑science, machine learning, and artificial intelligence.

Salary range: $ – $ (based on education, qualifications, experience, and location).

Benefits include medical, dental, vision, and other insurance benefits for employee and family; retirement benefits including 401(k); paid holidays; vacation; compassionate and sick days.

More information about benefits is available at

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.

As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

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