Senior Principal Scientist, Translational Clinical Biomarkers

Job Overview

Senior Principal Scientist (Sr. Director equivalent) – Immunology Biomarker Lead within Translational Clinical Biomarkers. This role provides strategic and scientific leadership in the design, execution, analysis, and communication of clinical biomarker strategies across our immune‑mediated therapeutic portfolio from discovery to pivotal clinical studies. The position is available in Rahway, NJ;
Boston/Cambridge, MA; or Upper Gwynedd, PA, based on candidate preference.

• Lead and shape integrated biomarker strategies across discovery, early‑ and late‑stage clinical programs, ensuring clear hypotheses, fit‑for‑purpose endpoints, and explicit linkage to key development decisions.
• Serve as the biomarker strategy lead within cross‑functional program teams, representing multi‑disciplinary teams in governance forums and addressing mission‑critical questions for forward and reverse translation.
• Inform portfolio strategy by advancing biomarker‑driven insights that inform target validation, patient selection, and go/no‑go decisions.
• Translate disease biology and therapeutic mechanism of action into clinically actionable biomarker strategies addressing critical program questions (e.g., proof of biology, pharmacodynamic effects, precision medicine, surrogate endpoints for efficacy).
• Drive selection and application of innovative biomarker approaches aligned with biological rationale and clinical utility.
• Lead biomarker sub‑teams and related working groups (clinical, discovery, translational, regulatory, bio‑stats, data science) to integrate scientific perspectives into cohesive strategies.
• Provide scientific leadership to enable hypothesis‑driven, decision‑focused biomarker strategies, growing and developing team members through mentorship.
• Champion biomarker analysis plans and deliver critical scientific input for interpreting complex datasets, producing rigorous and clinically meaningful conclusions.
• Clearly articulate insights to internal stakeholders, governance bodies, and external scientific audiences, supporting external engagement (publications, presentations, KOL interactions).
• Operate effectively in a fast‑moving, matrixed environment, leading highly matrixed organizations and influencing cross‑functional and senior stakeholders.

• Education:
  
  Ph.D. or M.D. with 12+ years of experience in Immunology or a related scientific discipline and expertise with autoimmune diseases and/or translational medicine.
• Deep expertise in immunology and immune‑mediated/inflammatory diseases, with experience in gastrointestinal/mucosal inflammation, rheumatology, and dermatology.
• Proven track record of driving translational strategies that inform clinical development decisions, including cross‑functional collaboration and partnership.
• Strong analytical and problem‑solving capabilities, translating complex data into clear, decision‑oriented insights.
• Excellent communication skills, including experience presenting to senior leadership and external stakeholders.
• Working knowledge of biostatistics, bioinformatics, and advanced data analytics.
• Strategic mindset focused on decision impact rather than data generation alone.
• Leadership presence and ability to influence cross‑functional and senior stakeholders.
• Direct managerial experience preferred; experience advancing precision medicine strategies is a plus.

• Salary range: $ – $, based on education, qualifications, experience, and geographic location.
• Annual bonus and long‑term incentive potential, if applicable.
• Comprehensive benefits package: medical, dental, vision, retirement (including 401(k)), paid holidays, vacation, compassionate and sick days.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.