Associate Principal Scientist, Preclinical Development

Job Description

As a Assoc Principal scientist, you will drive the creation of next‑generation mammalian cell lines using a
- systems-level approach
. You will be responsible for designing synthetic genetic circuits, managing large‑scale multi‑omics datasets, and utilizing Next‑Generation Sequencing (NGS) to ensure the stability and productivity of therapeutic cell lines.

• Cell Engineering & Synthetic Biology: Design and optimize complex DNA vector constructs and synthetic gene circuits to enhance protein expression in CHO cells. Use cutting‑edge gene-editing tools for targeted knock‑in/out strategies.
• Systems Biology Integration: Develop and apply computational models to understand cellular pathways and metabolism, predicting how genetic modifications impact global cell behavior and product quality.
• Big Data Analytics: Build and maintain data pipelines to process high‑dimensional datasets from high‑throughput screening. Apply machine learning (ML) or deep learning (DL) models to inform experimental design and predict cell line performance.
• NGS Characterization: Lead NGS workflows, from library preparation to bioinformatics analysis. Use NGS to verify monoclonality, transgene integrity, and integration sites.
• Cross‑Functional
  
  Collaboration:
  
  Partner with Upstream, Downstream, and Analytical teams to deliver integrated CMC solutions. Author technical reports for regulatory filings (IND/BLA).

• Education: Ph.D. in Molecular Biology, Bioinformatics, Systems Biology, Chemical Engineering, or a related field; or a Master's degree with 5‑8+ years of industry experience.
• Computational Proficiency: Strong programming skills in Python or R for biological data analysis.
  
  Experience with
  Linux/Unix environments and command‑line bioinformatics tools (BWA, GATK, Samtools).
• Wet‑Lab Expertise: Expertise in aseptic mammalian cell culture. Advanced molecular cloning techniques and genetic characterization (ddPCR, flow cytometry).
• NGS
  
  Experience:
  
  Proven track record in library construction and data management for DNA‑seq and RNA‑seq workflows.

US and Puerto Rico Residents Only.

We provide accommodations for candidates who need assistance during the application or hiring process.

The salary range for this role is $ - $.

The successful candidate will be eligible for annual bonus and long‑term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit the EEOC website.