Senior Scientist, Materials and Biophysical Characterization

Job Overview

The Materials and Biophysical Characterization group in the Pharmaceutical Analysis and Digital Technologies organization is seeking a highly self‑motivated and innovative Scientist - Senior Scientist level. This role focuses on biotherapeutics characterization, building mechanistic understanding of formulation, stability, device, and process interactions to ensure robustness and quality of drug substances and products.

Key responsibilities include developing and implementing biophysical and particle characterization tools, collaborating with process, formulation and device functions, authoring technical reports and regulatory documents, presenting technical data, and managing projects. The candidate will conduct independent research, publish findings, present at scientific conferences, and engage with external scientific societies.

Minimum Requirement:
Ph.D. in Biophysics, Biochemistry, Chemistry, Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences or related discipline (0‑4 years of relevant industry experience) or M.S. in the same or related discipline with 4‑8 years of relevant industry experience. Ph.D. candidates with expected degree conferment by Fall 2026 will be considered.

• Experience in the analysis of biologics, protein/peptide stability, and protein‑protein interactions.
• Experience with subvisible and submicron particle characterization tools (e.g., flow imaging microscopy, back grounded membrane imaging (BMI), flow cytometry, dynamic light scattering (DLS)).
• Hands‑on experience in biophysical characterization of proteins and peptides (e.g., Circular Dichroism (CD), Infrared Spectroscopy (IR), Differential Scanning Calorimetry (DSC), Analytical Ultracentrifugation (AUC)).
• Understanding of protein aggregation mechanisms and linkage between analytical methodologies.
• Ability to deliver complex objectives under aggressive timelines in a rapidly changing environment.
• Demonstrated initiative, creativity, and innovative problem‑solving skills.
• Strong teamwork and excellent oral and written communication skills; ability to work independently and cross‑functionally.

• Experience with characterization of lyophilized protein formulations.
• Experience with molecular modeling.
• Experience with biological formulation development and analytical method development.
• Familiarity with various biologics modalities including peptides, mAbs, ADCs, fusion proteins.

• Adaptability, Analytical Method Development, Assay Development, Bioanalytical Analysis, Biochemical Assays, Biomedical Engineering, Biophysics, Cell‑Based Assays, Chemical Engineering, Chromatographic Techniques, Circular Dichroism (CD), Differential Scanning Calorimetry (DSC), GMP Environments, Infrared Spectroscopy, Innovative Thinking, Nuclear Magnetic Resonance (NMR) Analysis, Pharmaceutical Sciences, Process Analytical Technology (PAT), Protein Interactions, Spectrophotometry, Spectroscopy, Strategic Thinking, Taking Initiative, Technical Data Analysis.

Salary range: $ - $, based on experience, education, qualifications, and other factors.

Eligible for annual bonus and long‑term incentive, if applicable. Comprehensive benefits package includes medical, dental, vision, retirement (401(k)), paid holidays, vacation, and compassionate and sick days.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit EEOC Know Your Rights EEOC GINA Supplement.