Principal Scientist, Upstream Process Development Group Lead

Our Scientists are our Inventors. Through innovative thinking, state-of-the-art facilities, cutting-edge science, and technology, we collaborate to deliver the next medical breakthroughs. We are looking for a collaborative, self-motivated scientific leader with expertise in downstream bioprocessing to join Biologics Process Research & Development (BPR&D) as a Senior Principal Scientist.

• Serve as a scientific leader to shape and drive innovation across the Biologics pipeline, strategy, and science.
• Anticipate and solve scientific and technical challenges across projects and functional teams, in a fast-paced, multidisciplinary environment.
• Lead the development of robust and scalable upstream processes for biologics in various stages of clinical development, as well as process characterization and regulatory filings for successful commercialization.
• Improve upstream processes by increasing efficiency and cost-effectiveness through research and innovation, while evaluating technologies and industry best practices.
• Collaborate with academia, industry, and vendors to facilitate the development and early adoption of novel process technologies.
• Contribute to strategic initiatives; work with senior leaders to establish overall project strategy and guide teams in its execution.
• Conceptualize, plan, and execute projects using effective organizational, prioritization, and problem‑solving skills.
• Stay updated on the scientific and regulatory landscape; contribute scientifically and build your reputation through conference participation.
• Represent BPR&D as a upstream bioprocess expert/co‑leader in internal and cross‑functional project teams.
• Direct supervision of 3-5 scientists, accountable for development and growth of a cohesive group and direct reports.
• Mentor and actively share expertise across teams; guide career development within and outside the group; build strong, collaborative connections in matrix teams.

• Ph.D. with 10+ years, MS with 12+ years, or BS with 14+ and Ph.D. with 6+ years, MS with 8+ years, or BS with 10+ years of industry experience in Chemical/Biochemical Engineering or a related field for Senior Principal Scientist position and Principal Scientist position, respectively.

• Strong fundamental knowledge and subject matter expertise in cell-culture process development for biologics, fed‑batch cell culture, bioreactor scale‑up and scale‑down, as well as recent advances, and challenges in the field.
• Expertise in independently conducting and directing the design, execution, analysis, and documentation of all stages of cell‑culture process development.
• Track record of accomplishments in upstream bioprocessing with a history of peer‑reviewed publications and presentations. Strong understanding of cell metabolism and biochemical pathways relevant to bioprocessing.
• Knowledge of biologics CMC development.
• Ability to adapt to and prioritize complex objectives under tight timelines in a rapidly changing environment.
• Experience leading internal and external cross‑functional, matrixed teams.
• Demonstrated scientific leadership with significant, measurable project impacts across a set of programs.
• Action‑oriented mindset with a capacity for creativity; ability to take initiative, innovate, iterate, and solve problems.
• Supervise, coach and mentor scientists to maximize talent development and utilization.
• Excellent interpersonal and communication skills.

• Leadership of CMC development teams.
• Experience with continuous biomanufacturing integrated with process‑analytical technologies.
• Knowhow of intensified inoculum and perfusion process development.
• Expertise in…