Senior Principal Scientist, Clinical Research, GI

Job Description

The Senior Director (Sr. Principal Scientist) leads planning and direction of clinical research activities for new or marketed oncology medicines across all phases of development, from pre‑clinical to post‑licensure. The role manages the full clinical development cycle, including study design, site placement, monitoring, data analysis, regulatory reporting, and publication.

• Evaluate pre‑clinical and translational work to generate early clinical development plans and IND applications.
• Develop clinical development strategies for investigational or marketed oncology drugs.
• Plan clinical trials (design, operational plans, settings) based on these strategies.
• Monitor and manage ongoing or new clinical trials for investigational or marketed oncology drugs.
• Analyze and summarize clinical findings to support safety and efficacy decisions, new drug applications, CGS reports, and publications.
• Participate in internal and joint research project teams relevant to new and marketed compound development.

• Supervise clinical scientists during study execution.
• Work closely with cross‑functional experts in commercialization, regulatory affairs, statistics, and manufacturing to manage clinical projects.
• Assist the Executive Director in ensuring corporate personnel are informed of study progress and relevant scientific questions.

• Stay current with scientific developments in the field.
• Identify scientifically strong investigators who can assist drug development.
• Establish communication with prominent clinical investigators, especially those capable of evaluating company drugs.
• Attend scientific meetings to maintain competency and awareness of research activities.

• Author detailed development documents, presentations, budgets, and position papers for internal and external audiences.
• Facilitate collaborations with external researchers worldwide.
• Travel on company business roughly 20 % of the time.

• M.D. or M.D./Ph.D.
• Minimum 2 years of clinical medicine experience in adult or pediatric oncology and/or hematology.
• Minimum 1 year of drug‑development, pharmaceutical industry, or biomedical research experience in academia or fellowship.
• Demonstrated record of scientific scholarship and achievement.
• Strong interpersonal and communication skills; ability to function in large cross‑functional teams.

• Successfully completed an ACGME medical oncology fellowship (or combined medical oncology/hematology or pediatric hematology).
• Board certified in adult or pediatric oncology (and/or hematology).
• Track record in clinical academic medicine focused on adult GI oncology, proficiency in the GI oncology treatment landscape, and academic publication experience.

• Clinical judgment
• Clinical medicine
• Clinical research
• Clinical trial development
• Clinical trials
• Data analysis
• Drug development
• Gastrointestinal cancer
• Gastrointestinal oncology
• Intellectual curiosity
• Mentorship

We are an Equal Employment Opportunity Employer and a federal contractor that provides accommodations for applicants with disabilities and complies with all affirmative action requirements.

Salary range: $ – $. The role may include annual bonus and long‑term incentive. Benefits include medical, dental, vision, retirement (401(k)), paid holidays, vacation, and compassionate and sick days.

US and Puerto Rico residents only. Travel required approximately 25% of the time.

No.

June 26 2026.